| Gene Symbol |
CERKL
|
| Entrez Gene |
375298
|
| Alt Symbol |
RP26
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ceramide kinase-like
|
| Other Description |
ceramide kinase-like protein
|
| Swissprots |
Q49MI2 Q5DVJ5 Q5DVJ2 Q49MH9 Q5DVJ4 Q49MI0 Q49MI1 B2RPL2 Q49MI3 Q6UZF6 B4DEY1 Q6ZP59
|
| Accessions |
EAX10984 Q49MI3 AJ640141 CAG26695 AJ697855 CAG26977 AJ697856 CAG26978 AJ697858 CAG26980 AK129976 BAC85266 AK293844 BAG57242 AY357073 AAR13670 AY690329 AAW47988 AY690330 AAW47989 AY690331 AAW47990 AY690332 AAW47991 AY690333 AAW47992 BC137498 AAI37499 BC137499 AAI37500 BM969366 HQ426666 AEK85692 HQ426667 AEK85693 HQ426668 AEK85694 HQ426669 AEK85687 HQ426670 AEK85688 HQ426671 AEK85695 HQ426672 AEK85696 HQ426673 AEK85697 HQ426674 AEK85698 HQ426675 AEK85689 HQ426676 AEK85690 HQ426677 AEK85699 HQ426678 AEK85700 HQ426679 AEK85686 JF290420 AEC33276 NM_001030311 NP_001025482 NM_001030312 NP_001025483 NM_001030313 NP_001025484 NM_001160277 NP_001153749 NM_201548 NP_963842 NR_027689 NR_027690
|
| Function |
Has no detectable ceramide-kinase activity. Overexpression of CERKL protects cells from apoptosis in oxidative stress conditions. {ECO:0000269|PubMed:15708351, ECO:0000269|PubMed:19158957}.
|
| Subcellular Location |
Cytoplasm. Nucleus, nucleolus. Note=Enriched in nucleoli. May shuttle between nucleus and cytoplasm. Isoform 5 is not enriched in the nucleoli.
|
| Tissue Specificity |
Isoform 1 and isoform 2 are expressed in adult retina, liver and pancreas as well as in fetal brain, lung and kidney. Isoform 3 is expressed in adult retina as well as in fetal lung and liver. Isoform 4 is expressed in adult retina, lung and kidney as well as in fetal lung and liver. Moderately expressed in retina, kidney, lung, testis, trachea, and pancreas. Weakly expressed in brain, placenta and liver. {ECO:0000269|PubMed:14681825, ECO:0000269|PubMed:15708351, ECO:0000269|PubMed:19158957}.
|