HIPK1

Gene Symbol	HIPK1
Entrez Gene	204851
Alt Symbol	Myak, Nbak2
Species	Human
Gene Type	protein-coding
Description	homeodomain interacting protein kinase 1
Other Description	homeodomain interacting protein kinase 1-like protein|homeodomain-interacting protein kinase 1|nuclear body associated kinase 2b|nuclear body-associated kinase 2
Swissprots	A6NJ34 Q8NDN5 Q5SQL5 Q8TBZ1 Q8NEB6 Q5SQL4 Q5SQL2 Q8IYD7 O75125 Q86Z02
Accessions	EAW56585 EAW56586 EAW56587 EAW56588 EAW56589 EAW56590 EAW56591 EAW56592 EAW56593 Q86Z02 AA995033 AB014530 BAA31605 AB089957 BAC57075 AK122662 BAG53650 AK302726 BAG63945 AL833829 CAD38689 BC028408 AAH28408 BC033012 AAH33012 BC033339 BC036057 AAH36057 BC052493 XM_005270609 XP_005270666 XM_005270610 XP_005270667 XM_005270611 XP_005270668 XM_005270612 XP_005270669 XM_005270613 XP_005270670 XM_006710443 XP_006710506 XM_011540977 XP_011539279 XM_011540978 XP_011539280 XM_011540979 XP_011539281 XM_011540980 XP_011539282 NM_152696 NP_689909 NM_181358 NP_852003 NM_198268 NP_938009 NM_198269 NP_938010
Function	Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti- oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation. {ECO:0000269|PubMed:12702766, ECO:0000269|PubMed:12968034, ECO:0000269|PubMed:15701637, ECO:0000269|PubMed:16390825, ECO:00
Subcellular Location	Nucleus. Cytoplasm. Note=Predominantly nuclear. Translocates from nucleus to cytoplasm in response to stress stimuli via SENP1-mediated desumoylation.
Tissue Specificity	Ubiquitously expressed with highest levels in skeletal muscle and heart. Overexpressed in breast cancer cell lines. Isoform 2 is highly expressed in testis. {ECO:0000269|PubMed:12529400, ECO:0000269|PubMed:12702766}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human HIPK1 protein fragment - ab60867 from Abcam Category Protein Prices $294.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human HIPK1 full length protein - ab132499 from Abcam Category Protein Source Wheat germ Species Human

Human HIPK1 protein fragment - ab165908 from Abcam Category Protein Source Wheat germ Species Human

HIPK1 Antibody Blocking Peptide - LS-E1697 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HIPK1 Antibody Blocking Peptide - LS-E20215 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HIPK1 Recombinant Protein - H00204851-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

HIPK1 Partial Recombinant Protein - H00204851-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human HIPK1 Protein - P3869 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 5 µg Source Insect Species Human

HIPK1-Antibody-C-term-Blocking-peptide - BP12465b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

HIPK1 Blocking Peptide - 33R-7200 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

HIPK1 - H00204851-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

HIPK1 - H00204851-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

HIPK1 - H00204851-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

HIPK1 - H00204851-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

HIPK1 - P3869 from Acris Antibodies Category Protein Prices $1,230.00 Sizes 5 µg Species Human

Recombinant Human HIPK1, GST-tagged - HIPK1-516H from Creative Biomart Category Protein Source Sf9.

Recombinant Human HIPK1, GST-tagged - HIPK1-524H from Creative Biomart Category Protein Source Sf21 cells.

Recombinant Human HIPK1 (Active), GST-tagged - HIPK1-1413H from Creative Biomart Category Protein Source Sf9 Cells Species Human

Recombinant Human Homeodomain-interacting protein kinase 1(HIPK1) ,partial - CSB-YP803159HU CSB-EP803159HU CSB-BP803159HU CSB-MP803159HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Homeodomain Interacting Protein Kinase 1 (HIPK1) - RPC526Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Human HIPK1 GST - CSI13414 from Cell Science Prices $615.00 Sizes 10 μg Species Human

Recombinant Homeodomain Interacting Protein Kinase 1 (HIPK1) - RPC526Hu01 from Cloud-clone Category Protein Source E.coli Species Human

HIPK1 Recombinant Protein Antigen - NBP1-82981PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

HIPK1 Protein, active, 250 µg - 14-679M from EMD Millipore Category Protein Prices $2,441.00 Sizes 250 µg also available in 10 μg size . (cat#14-679) and in bulk (cat#14-679-K) Source HIPK1 expressed by baculovirus in Sf21 cells.

HIPK1 Protein, active, 10 µg - 14-679 from EMD Millipore Category Protein Prices $329.00 Sizes 10 µg Source HIPK1 expressed by baculovirus in Sf21 cells.

Search more