| Gene Symbol | ERG9 |
|---|---|
| Entrez Gene | 856597 |
| Alt Symbol | - |
| Species | Yeast |
| Gene Type | protein-coding |
| Description | bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase |
| Other Description | - |
| Swissprots | D3DLD8 P29704 |
| Accessions | DAA06882 P29704 NM_001179321 NP_012060 |
| Function | Catalyzes the condensation of 2 two farnesyl pyrophosphate moieties to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway. Required for the biosynthesis of ergosterol. May also have a regulatory role regulating the flux of isoprene intermediates through the sterol pathway. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. ERG9 is also essential for cell growth in yeast. {ECO:0000269|PubMed:1807826, ECO:0000269|PubMed:2068081, ECO:0000269|PubMed:8323279}. |
| Subcellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome. |
| Top Pathways | Sesquiterpenoid and triterpenoid biosynthesis, Steroid biosynthesis |