PIN1

Gene Symbol	PIN1
Entrez Gene	5300
Alt Symbol	DOD, UBL5
Species	Human
Gene Type	protein-coding
Description	peptidylprolyl cis/trans isomerase, NIMA-interacting 1
Other Description	PPIase Pin1|peptidyl-prolyl cis-trans isomerase NIMA-interacting 1|protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1|rotamase Pin1
Swissprots	A8K4V9 Q13526 Q53X75
Accessions	AAM81970 EAW84057 EAW84058 EAW84059 Q13526 AF086512 AK092970 AK097558 BAG53486 AK291074 BAF83763 BC002899 AAH02899 BC031971 AAH31971 BG912418 BI827520 BI827672 BT019331 AAV38138 CA439440 CD675162 CR407654 CAG28582 DQ892978 ABM83904 DQ896226 ABM87225 U49070 AAC50492 XM_011528068 XP_011526370 NM_006221 NP_006212 NR_038422 NR_038830
Function	Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr- Pro) motifs in a subset of proteins, resulting in conformational changes in the proteins (PubMed:21497122, PubMed:22033920). Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK (PubMed:16644721). Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (PubMed:15664191). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of
Subcellular Location	Nucleus {ECO:0000269|PubMed:16476580}. Nucleus speckle {ECO:0000269|PubMed:21497122}. Cytoplasm {ECO:0000269|PubMed:21497122}. Note=Colocalizes with NEK6 in the nucleus (PubMed:16476580). Mainly localized in the nucleus but phosphorylation at Ser-71 by DAPK1 results in inhibition of its nuclear localization (PubMed:21497122). {ECO:0000269|PubMed:16476580}.
Tissue Specificity	The phosphorylated form at Ser-71 is expressed in normal breast tissue cells but not in breast cancer cells. {ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:21497122}.
Top Pathways	RIG-I-like receptor signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Pin1 ELISA kit - ab136946 from Abcam Category ELISA Kit Prices $625.00 Sizes 1 x 96 tests Sensitivity 15.9 pg/ml Range 62.5 pg/ml - 2000 pg/ml

Human PIN1 ELISA Kit (Sandwich ELISA) - LS-F12335 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 78 Range 78-5000 pg/ml

Human/Mouse Total Pin1 DuoSet IC ELISA - DYC2294-2 from R&D Systems Category ELISA Kit Prices $329.00 Sizes 1 kit (for 2 Plates) Range 469.00 - 30,000 pg/mL

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, PIN1, Human, ELISA Kit - E7189h from ARP American Research Products Category ELISA Kit Prices $736.00 Sizes 96 t Range 78-5000 pg/mL

Protein (peptidylprolyl cis/trans isomerase)NIMA-interacting 1, PIN1, Human, ELISA Kit - CSB-E11308h from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 0.39pg/ml Range 1.56 pg/ml-100 pg/ml

peptidylprolyl cis/trans isomerase, NIMA-interacting 1, ELISA Kit - MBS702800 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human PIN1 is typically less than 0.39 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 1.56 pg/ml -100 pg/ml.

Pin1 ELISA Kit - DEIA6468 from Creative Diagnostics Category ELISA Kit Sensitivity The sensitivity of the assay, defined as the concentration of Pin1 measured at 2 standard deviations from the mean of 20 zeros along the standard curve, was determined to be 15.9 pg/mL

Human protein(peptidylprolyl cis/trans isomerase)NIMA-interacting 1,PIN1 ELISA Kit - CSB-E11308h from Cusabio Category ELISA Kit Sensitivity 0.39 pg/ml Range 1.56 pg/ml-100 pg/ml

Bovine PIN1 ELISA Kit (Custom ELISA) - LS-F20104 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 78-5000 pg/ml

Mouse PIN1 ELISA Kit (Custom ELISA) - LS-F20105 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 78-5000 pg/ml

Human Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 ELISA Kit - abx251719 from Abbexa Category ELISA Kit Range 78 pg/ml - 5000 pg/ml

Human Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 ELISA Kit - EKE54697 from Biomatik Category ELISA Kit Prices $809.60, $3,440.80, $6,476.80 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 34 pg/mL Range 78-5000 pg/mL

PIN1 - EKH4722 from Nordic BioSite Sensitivity 46.9pg/ml Range 78-5000pg/ml

PIN1 ELISA Kit (Human) : 96 Wells (OKEH01811) - OKEH01811 from Aviva Systems Biology Category ELISA Kit Prices $480.00 Sizes 96 wells Sensitivity < 34 pg/mL Range 78 - 5000 pg/mL

Human PIN1 ELISA Kit - E028594 from Biobool Category ELISA Kit Sensitivity The minimum detectable dose of human PIN1 is typically less than 0.39 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mea

Human Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 ELISA Kit - EK4752 from Signalway Antibody Category ELISA Kit Prices $739.00 Sizes 1x96t Range 78-5000 pg/mL

anti-Pin1 antibody - ARG10687 from Arigo Biolaboratories Category ELISA Kit

anti-Pin1 antibody - ARG55420 from Arigo Biolaboratories Category ELISA Kit

anti-Pin1 antibody - ARG64069 from Arigo Biolaboratories Category ELISA Kit

Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 1 (PIN1) , ELISA Kit - MBS2088178 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity <0.054ng/mL Range 0.156-10ng/mL

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, ELISA Kit - MBS761897 from MyBioSource Category ELISA Kit Prices $295.00, $390.00, $1,615.00, $3,015.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 46.9pg/ml Range 78-5000pg/ml

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, ELISA Kit - MBS9428578 from MyBioSource Category ELISA Kit Prices $670.00 Sizes 96 tests Sensitivity Less than 34pg/mL Range 78-5000 pg/mL

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, ELISA Kit - MBS2880670 from MyBioSource Category ELISA Kit Prices $430.00, $570.00, $2,515.00, $4,520.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 78-5000 pg/mL

Human PIN1 ELISA Kit (Sandwich ELISA) - LS-F33977 from LifeSpan Bioscience Category ELISA Kit Sensitivity 46.9 Range 78-5000 pg/ml

Human PIN1 ELISA Kit (Sandwich ELISA) - LS-F39041 from LifeSpan Bioscience Category ELISA Kit Sensitivity 0.054 Range 78-5000 pg/ml

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