PIN1

Gene Symbol	PIN1
Entrez Gene	5300
Alt Symbol	DOD, UBL5
Species	Human
Gene Type	protein-coding
Description	peptidylprolyl cis/trans isomerase, NIMA-interacting 1
Other Description	PPIase Pin1|peptidyl-prolyl cis-trans isomerase NIMA-interacting 1|protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1|rotamase Pin1
Swissprots	A8K4V9 Q13526 Q53X75
Accessions	AAM81970 EAW84057 EAW84058 EAW84059 Q13526 AF086512 AK092970 AK097558 BAG53486 AK291074 BAF83763 BC002899 AAH02899 BC031971 AAH31971 BG912418 BI827520 BI827672 BT019331 AAV38138 CA439440 CD675162 CR407654 CAG28582 DQ892978 ABM83904 DQ896226 ABM87225 U49070 AAC50492 XM_011528068 XP_011526370 NM_006221 NP_006212 NR_038422 NR_038830
Function	Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr- Pro) motifs in a subset of proteins, resulting in conformational changes in the proteins (PubMed:21497122, PubMed:22033920). Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK (PubMed:16644721). Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (PubMed:15664191). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of
Subcellular Location	Nucleus {ECO:0000269|PubMed:16476580}. Nucleus speckle {ECO:0000269|PubMed:21497122}. Cytoplasm {ECO:0000269|PubMed:21497122}. Note=Colocalizes with NEK6 in the nucleus (PubMed:16476580). Mainly localized in the nucleus but phosphorylation at Ser-71 by DAPK1 results in inhibition of its nuclear localization (PubMed:21497122). {ECO:0000269|PubMed:16476580}.
Tissue Specificity	The phosphorylated form at Ser-71 is expressed in normal breast tissue cells but not in breast cancer cells. {ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:21497122}.
Top Pathways	RIG-I-like receptor signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Pin1 full length protein - ab51230 from Abcam Category Protein Prices $239.00, $939.00 Sizes 100 µg, 500 µg Source E. coli Species Human

Human Pin1 full length protein - ab40538 from Abcam Category Protein Source E. coli Species Human

Human Pin1 peptide - ab12397 from Abcam Category Peptide Source CHO

PIN1 Antibody Blocking Peptide - LS-E26190 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PIN1 Antibody Blocking Peptide - LS-E23076 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PIN1 Antibody Blocking Peptide - LS-E9874 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Pin1 Partial Recombinant Protein - H00005300-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Pin1 Protein - H00005300-P01 from Novus Biologicals Category Protein Prices $529.00 Sizes 25 µg Source Wheat Germ Species Human

Recombinant Human Pin1 Protein - NBC1-18415 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Species Human

Pin1 Recombinant Protein - P3447 from Novus Biologicals Category Protein Prices $669.00 Sizes 100 µg Species Human

PIN1-Antibody-Center-Blocking-Peptide - BP8959c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PAPIN/PDZK3 blocking peptide - GTX26037-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

PIN1 blocking peptide - GTX89227-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

Recombinant Human Pin1, HRP-conjugated Protein - HRP2294 from R&D Systems Category Protein Prices $299.00 Sizes 250 µl Species Human

PIN1 Protein (OPPA00850) - OPPA00850 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human DOD protein - orb84382 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source E. coli Species Human

Human DOD protein - orb84429 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source E. coli Species Human

Human PIN1 protein - orb90219 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E.coli Species Human

Pin 1 protein - 30R-1036 from Fitzgerald Category Protein Prices $350.00 Sizes 100 µg Source E.coli

Human PIN1 Protein - abx068455 from Abbexa Category Protein Source E.coli Species Human

PIN1 (phospho-Ser16) Blocking Peptide - abx063087 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Monkey, Pig, Zebrafish

PIN1 Peptide - AC21-1021-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

PIN1 - SA6039 from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

PIN1 - SA6039X from Acris Antibodies Category Protein Prices $785.00 Sizes 500 µg Source E. coli Species Human

PIN1 - H00005300-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

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