Gene Symbol | FPR3 |
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Entrez Gene | 2359 |
Alt Symbol | FML2_HUMAN, FMLPY, FPRH1, FPRH2, FPRL2, RMLP-R-I |
Species | Human |
Gene Type | protein-coding |
Description | formyl peptide receptor 3 |
Other Description | FMLP-R-II|FMLP-related receptor II|N-formyl peptide receptor 3|formyl peptide receptor-like 2 |
Swissprots | P25089 |
Accessions | AAA52474 AAC72102 AAP20654 EAW72045 P25089 AK123030 AK292541 BAF85230 BC059388 AAH59388 BC069070 AAH69070 BC069593 AAH69593 BC069812 AAH69812 CB996360 M76673 AAA58482 XM_011526687 XP_011524989 NM_002030 NP_002021 |
Function | Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Top Pathways | Staphylococcus aureus infection, Neuroactive ligand-receptor interaction |
FPR3 CRISPR/Cas9 KO Plasmid (h) - sc-406910 from Santa Cruz Biotechnology
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FPR3 HDR Plasmid (h) - sc-406910-HDR from Santa Cruz Biotechnology
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FPR3 Double Nickase Plasmid (h) - sc-406910-NIC from Santa Cruz Biotechnology
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FPR3 Double Nickase Plasmid (h2) - sc-406910-NIC-2 from Santa Cruz Biotechnology
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FPR3 CRISPR Activation Plasmid (h) - sc-406910-ACT from Santa Cruz Biotechnology
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FPR3 CRISPR Activation Plasmid (h2) - sc-406910-ACT-2 from Santa Cruz Biotechnology
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FPR3 Lentiviral Activation Particles (h) - sc-406910-LAC from Santa Cruz Biotechnology
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FPR3 Lentiviral Activation Particles (h2) - sc-406910-LAC-2 from Santa Cruz Biotechnology
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FPR3 siRNA (h) - sc-45643 from Santa Cruz Biotechnology
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FPR3 shRNA Plasmid (h) - sc-45643-SH from Santa Cruz Biotechnology
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FPR3 shRNA (h) Lentiviral Particles - sc-45643-V from Santa Cruz Biotechnology
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FPRL2/FPR3 RNAi - H00002359-R02 from Novus Biologicals
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MISSION® esiRNA - EHU008181 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8928 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8928 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09067 from Sigma-Aldrich
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FPR3 siRNA (Human) - CRH1650 from Cohesion Biosciences
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FPR3 - MBS8220789 from MyBioSource
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FPR3 CRISPR/Cas9 KO Plasmid (h2) - sc-406910-KO-2 from Santa Cruz Biotechnology
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FPR3 HDR Plasmid (h2) - sc-406910-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human FPR3 (NM_002030.3) - SHH296961 from Creative biogene
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Human FPR3 siRNA - orb262152 from Biorbyt
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FPR3 shRNA Plasmid (Human) - CHH1650 from Cohesion Biosciences
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FPR3 miRNA 3'UTR clone - MiUTR1H-03844 from Creative biogene
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