| Gene Symbol | CFD |
|---|---|
| Entrez Gene | 1675 |
| Alt Symbol | ADIPSIN, ADN, DF, PFD |
| Species | Human |
| Gene Type | protein-coding |
| Description | complement factor D (adipsin) |
| Other Description | C3 convertase activator|D component of complement (adipsin)|complement factor D|complement factor D preproprotein|properdin factor D |
| Swissprots | Q86VJ5 Q8WZB4 Q8N4E0 Q5U5S1 P00746 B4DV76 |
| Accessions | EAW69588 P00746 AJ313463 CAC48304 AK300963 BAG62588 BC034529 AAH34529 BC040146 AAH40146 BC051001 AAH51001 BC057807 AAH57807 BG573629 BI763909 CR536575 CAG38812 DQ884409 ABI63376 M84526 AAA35527 NM_001928 NP_001919 |
| Function | Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway. |
| Subcellular Location | Secreted. |
| Top Pathways | Complement and coagulation cascades, Staphylococcus aureus infection |