| Gene Symbol | CENPA |
|---|---|
| Entrez Gene | 1058 |
| Alt Symbol | CENP-A, CenH3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | centromere protein A |
| Other Description | centromere autoantigen A|centromere protein A, 17kDa|centromere-specific histone|histone H3-like centromeric protein A |
| Swissprots | Q53T74 P49450 D6W544 Q9BVW2 |
| Accessions | AAB47505 AAX93267 EAX00669 EAX00670 EAX00671 EAX00672 P49450 BC000881 AAH00881 BC002703 AAH02703 BC011013 BT007246 AAP35910 HQ448742 ADQ33220 JF432571 ADZ15788 U14518 AAA57416 NM_001042426 NP_001035891 NM_001809 NP_001800 |
| Function | Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro). {ECO:0000269|PubMed:20739937, ECO:0000269|PubMed:21478274}. |
| Subcellular Location | Nucleus. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the kinetochore domain of centromeres. Occupies a compact domain at the inner kinetochore plate stretching across 2 thirds of the length of the constriction but encompassing only one third of the constriction width and height. |