Gene Symbol | ATG9B |
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Entrez Gene | 285973 |
Alt Symbol | APG9L2, NOS3AS, SONE |
Species | Human |
Gene Type | protein-coding |
Description | autophagy related 9B |
Other Description | APG9-like 2|ATG9 autophagy related 9 homolog B|autophagy 9-like 2 protein|autophagy-related protein 9B|endothelial nitric oxide synthase antisense|nitric oxide synthase 3-overlapping antisense gene protein |
Swissprots | Q8N8I8 Q674R7 A1A5D3 Q6JRW5 |
Accessions | Q674R7 AI221785 AI243432 AI827483 AK096734 BAC04853 AY316116 AAQ86941 AY515311 AAS87212 BC128587 AAI28588 BK004019 DAA05200 XM_011516064 XP_011514366 XM_011516065 XP_011514367 XM_011516066 XP_011514368 NM_173681 NP_775952 NR_073169 |
Function | Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:18936157}; Multi-pass membrane protein {ECO:0000269|PubMed:18936157}. Note=Under amino acid starvation or rapamycin treatment, redistributes from a juxtanuclear clustered pool to a dispersed peripheral cytosolic pool. The starvation- induced redistribution depends on ULK1 and ATG13. |
Tissue Specificity | Highly expressed in placenta (trophoblast cells) and pituitary gland. Not expressed in vascular endothelial. {ECO:0000269|PubMed:15234981}. |
Atg9b CRISPR/Cas9 KO Plasmid (h) - sc-406894 from Santa Cruz Biotechnology
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Atg9b HDR Plasmid (h) - sc-406894-HDR from Santa Cruz Biotechnology
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Atg9b Double Nickase Plasmid (h) - sc-406894-NIC from Santa Cruz Biotechnology
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Atg9b Double Nickase Plasmid (h2) - sc-406894-NIC-2 from Santa Cruz Biotechnology
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Atg9b CRISPR Activation Plasmid (h) - sc-406894-ACT from Santa Cruz Biotechnology
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Atg9b CRISPR Activation Plasmid (h2) - sc-406894-ACT-2 from Santa Cruz Biotechnology
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Atg9b Lentiviral Activation Particles (h) - sc-406894-LAC from Santa Cruz Biotechnology
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Atg9b Lentiviral Activation Particles (h2) - sc-406894-LAC-2 from Santa Cruz Biotechnology
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Atg9b siRNA (h) - sc-89347 from Santa Cruz Biotechnology
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Atg9b shRNA Plasmid (h) - sc-89347-SH from Santa Cruz Biotechnology
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Atg9b shRNA (h) Lentiviral Particles - sc-89347-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN3657 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3657 from Sigma-Aldrich
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ATG9B siRNA (Human) - CRJ7141 from Cohesion Biosciences
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ATG9B - MBS8206895 from MyBioSource
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shRNA set against Human ATG9B (NM_173681.5) - SHH242210 from Creative biogene
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Human ATG9B siRNA - orb277642 from Biorbyt
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ATG9B shRNA Plasmid (Human) - CHJ7141 from Cohesion Biosciences
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ATG9B miRNA 3'UTR clone - MiUTR3H-12350 from Creative biogene
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