| Gene Symbol | Aco1 |
|---|---|
| Entrez Gene | 11428 |
| Alt Symbol | Aco-1, Irebp, Irp1 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | aconitase 1 |
| Other Description | IRE-BP 1|citrate hydro-lyase|cytoplasmic aconitase|cytoplasmic aconitate hydratase|iron regulatory protein 1|iron-responsive element-binding protein 1 |
| Swissprots | Q99K54 Q3TQ15 P28271 |
| Accessions | CAD20353 EDL05446 P28271 AK027914 AK085951 AK129025 AK163985 BAE37570 AK178044 AK178972 AK187955 AK194174 AK201556 AK207292 AK216262 BB854442 BC005454 AAH05454 BC020360 BY145469 X61147 CAA43455 NM_007386 NP_031412 |
| Function | Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm. |
| Top Pathways | Citrate cycle (TCA cycle), Glyoxylate and dicarboxylate metabolism, Biosynthesis of amino acids, 2-Oxocarboxylic acid metabolism, Carbon metabolism |