| Gene Symbol |
HIST1H2BN
|
| Entrez Gene |
8341
|
| Alt Symbol |
H2B/d, H2BFD
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
histone cluster 1, H2bn
|
| Other Description |
H2B histone family, member D|histone 1, H2bn|histone H2B type 1-N|histone H2B.d
|
| Swissprots |
Q99877 B2R5L4 Q96FB7 Q494S8
|
| Accessions |
AAN06697 CAB05938 EAX03114 EAX03115 EAX03116 EAX03117 Q99877 AK312228 BAG35161 BC009783 BC011372 BC101411 AAI01412 BC101412 AAI01413 BC101413 AAI01414 DQ891028 ABM81954 DQ894207 ABM85133 NM_003520 NP_003511
|
| Function |
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
|
| Subcellular Location |
Nucleus. Chromosome.
|
| Top Pathways |
Systemic lupus erythematosus, Viral carcinogenesis, Alcoholism
|