| Gene Symbol | VAMP7 |
|---|---|
| Entrez Gene | 6845 |
| Alt Symbol | SYBL1, TI-VAMP, TIVAMP, VAMP-7 |
| Species | Human |
| Gene Type | protein-coding |
| Description | vesicle-associated membrane protein 7 |
| Other Description | synaptobrevin-like 1|synaptobrevin-like protein 1|tetanus neurotoxin-insensitive VAMP|tetanus-insensitive VAMP |
| Swissprots | Q9H4A7 Q53GY7 Q7Z409 P51809 |
| Accessions | CAB96816 EAW55877 EAW55878 EAW55879 EAW55880 EAW55881 EAW55882 EAW55883 P51809 AI042181 AI522002 AJ295938 CAC16891 AJ549301 CAD70593 AK222794 BAD96514 AK293525 BAG57007 AK295605 BAG58491 AK297385 BAG59826 AK312658 BAG35541 AM393132 CAL38010 BC056141 AAH56141 DC341378 X92396 CAA63133 XM_011531188 XP_011529490 XM_011545653 XP_011543955 NM_001145149 NP_001138621 NM_001185183 NP_001172112 NM_005638 NP_005629 NR_033714 NR_033715 |
| Function | Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation. {ECO:0000269|PubMed:10888671, ECO:0000269|PubMed:16677249, ECO:0000269|PubMed:18042464}. |
| Subcellular Location | Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Late endosome membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000269|PubMed:17897319}; Single-pass type IV membrane protein {ECO:0000269|PubMed:17897319}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Note=In immature neurons expression is localized in vesicular structures in axons and dendrites while in mature neurons it is localized to the somatodendritic region. Colocalizes with LAMP1 in kidney cells. Localization to the endoplasmic reticulum membrane was observed in the intestine but not in liver or k |
| Tissue Specificity | Detected in all tissues tested. |
| Top Pathways | SNARE interactions in vesicular transport |