| Gene Symbol |
CORO7
|
| Entrez Gene |
79585
|
| Alt Symbol |
0610011B16Rik, CRN7, POD1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
coronin 7
|
| Other Description |
70 kDa WD repeat tumor rejection antigen homolog|coronin-7
|
| Swissprots |
I3L416 Q17RK4 B4DFD6 B4DL18 P57737
|
| Accessions |
EAW85307 EAW85308 EAW85310 P57737 AK025674 BAB15211 AK094596 BAG52896 AK097238 BAG53439 AK126176 AK294045 BAG57397 AK296723 BAG59311 AK296807 BAG59380 AK303353 BAG64414 AK309327 AK309763 BC117289 AAI17290 BC117291 AAI17292 BM671637 DA094935 DR155527 HQ258676 ADR83427 NM_001201472 NP_001188401 NM_001201473 NP_001188402 NM_024535 NP_078811
|
| Function |
F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post- Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology. {ECO:0000269|PubMed:16905771, ECO:0000269|PubMed:24768539}.
|
| Subcellular Location |
Golgi apparatus membrane. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Note=Predominantly cytosolic. Detected on vesicle-like cytoplasmic structures and on the cis-Golgi. Not associated with actin filaments.
|
| Tissue Specificity |
Widely expressed. Expressed in the spleen, peripheral leukocytes, testes, brain, thymus and small intestine. {ECO:0000269|PubMed:21130766}.
|