| Gene Symbol | GalNAc-T2 |
|---|---|
| Entrez Gene | 32836 |
| Alt Symbol | CG6394, Dmel\CG6394, PGANT7, anon-WO02059370.15, dGalNAc-T2, pgant7 |
| Species | Drosophila |
| Gene Type | protein-coding |
| Description | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 |
| Other Description | CG6394-PA|CG6394-PB|CG6394-PC|GalNAc-T2-PA|GalNAc-T2-PB|GalNAc-T2-PC|polypeptide GalNAc transferase 7 |
| Swissprots | A4V4R2 Q8MV48 Q5U0W9 Q95TN2 Q9VWT6 Q95RJ3 |
| Accessions | AAF48851 AAN09470 AHN59876 Q8MV48 AY268068 AAQ56704 BT016123 AAV37008 NM_001298477 NP_001285406 NM_133073 NP_573301 NM_167623 NP_728178 |
| Function | Glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide. In contrast to other proteins of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified. Prefers the monoglycosylated Muc5AC-3 as substrate. |
| Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
| Tissue Specificity | Expressed in developing oocytes and egg chambers. During embryonic stages 9-11, expressed in the primordium of the foregut, midgut and hindgut. Expressed in the salivary glands from embryonic stage 12 onwards. During embryonic stages 12-13, expressed in the posterior midgut and hindgut. During embryonic stages 14-15, expression continues in the hindgut. During embryonic stages 16-17, expressed in the antennomaxillary complex. In third instar larvae, ubiquitously expressed in wing, with increased expression in the notum and ventral wing pouch, eye-antennal, leg and haltere imaginal disks. {ECO:0000269|PubMed:12829714, ECO:0000269|PubMed:16251381}. |
| Top Pathways | Mucin type O-Glycan biosynthesis |