| Gene Symbol | CREB1 |
|---|---|
| Entrez Gene | 1385 |
| Alt Symbol | CREB |
| Species | Human |
| Gene Type | protein-coding |
| Description | cAMP responsive element binding protein 1 |
| Other Description | CREB-1|active transcription factor CREB|cAMP-response element-binding protein-1|cAMP-responsive element-binding protein 1|cyclic AMP-responsive element-binding protein 1|transactivator protein |
| Swissprots | P16220 Q9UMA7 Q6V963 P21934 |
| Accessions | AAB20597 AAD13869 AAX88961 AAX93174 CAM91158 EAW70405 EAW70406 EAW70407 EAW70408 EAW70409 EAW70410 P16220 AK091534 AK095116 AK123952 AK126342 AK298740 BAH12862 AK302333 BAH13677 AK312747 BAG35615 AK315226 BAG37655 AW205606 AY347527 AAQ24858 BC010636 AAH10636 BC095407 AAH95407 BT019509 AAV38316 CR407617 CAG28545 DC366797 DQ891157 ABM82083 DQ894336 ABM85262 M27691 AAA35715 M34356 AAA35716 S78693 AAB34949 S78695 AAB34950 X55545 CAA39151 X60003 CAA42620 XM_011510645 XP_011508947 XM_011510646 XP_011508948 XM_011510647 XP_011508949 XM_011510648 XP_011508950 XM_011510649 XP_011508951 XM_011510650 XP_011508952 XM_011510651 XP_011508953 XM_011510652 XP_011508954 XM_011510653 XP_011508955 XR_241289 XR_241290 XR_241292 XR_427071 XR_922862 NM_004379 NP_004370 NM_134442 NP_604391 |
| Function | Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells. |
| Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00312, ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:12552083}. |
| Top Pathways | Prostate cancer, Adrenergic signaling in cardiomyocytes, cGMP-PKG signaling pathway, Thyroid hormone synthesis, TNF signaling pathway |