| Gene Symbol | clp1 |
|---|---|
| Entrez Gene | 431824 |
| Alt Symbol | - |
| Species | Xenopus |
| Gene Type | protein-coding |
| Description | cleavage and polyadenylation factor I subunit 1 |
| Other Description | CLP1, cleavage and polyadenylation factor I subunit, homolog|polynucleotide kinase Clp1|polyribonucleotide 5'-hydroxyl-kinase Clp1|pre-mRNA cleavage complex II protein Clp1 |
| Swissprots | Q6NS21 |
| Accessions | Q6NS21 BC070530 AAH70530 NM_001091318 NP_001084787 |
| Function | Polynucleotide kinase that can phosphorylate the 5'- hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Its role in tRNA splicing and maturation is required for cerebellar development. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'- terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their |
| Subcellular Location | Nucleus {ECO:0000255|HAMAP-Rule:MF_03035}. |
| Top Pathways | mRNA surveillance pathway |