| Gene Symbol | LPAR1 |
|---|---|
| Entrez Gene | 1902 |
| Alt Symbol | EDG2, GPR26, Gpcr26, LPA1, Mrec1.3, VZG1, edg-2, rec.1.3, vzg-1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | lysophosphatidic acid receptor 1 |
| Other Description | LPA receptor 1|LPA-1|endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2|lysophosphatidic acid receptor Edg-2|ventricular zone gene 1 |
| Swissprots | P78351 O00722 B4DK36 O00656 Q92633 |
| Accessions | CAC34034 CAE91525 EAW59068 EAW59069 Q92633 AK022808 BAG51118 AK290287 BAF82976 AK296374 BAG59048 AK298590 BAG60780 AK299279 BAG61296 AY322546 AAP84359 BC030615 AAH30615 BC036034 AAH36034 BC073167 AAH73167 BI461641 U78192 AAC00530 U80811 AAC51139 Y09479 CAA70686 XM_005251781 XP_005251838 XM_005251782 XP_005251839 NM_001401 NP_001392 NM_057159 NP_476500 |
| Function | Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in a manner that is dependent on RALA activation. {ECO:0000269|PubMed:19306925}. |
| Subcellular Location | Cell surface {ECO:0000269|PubMed:19306925}. Cell membrane {ECO:0000269|PubMed:19306925}; Multi-pass membrane protein {ECO:0000269|PubMed:19306925}. Note=Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA colocalizes with RALA in the endocytic vesicles. |
| Tissue Specificity | Expressed in many adult organs, including brain, heart, colon, small intestine, placenta, prostate, ovary, pancreas, testes, spleen, skeletal muscle, and kidney. Little or no expression in liver, lung, thymus, or peripheral blood leukocytes. |
| Top Pathways | Gap junction, PI3K-Akt signaling pathway, Rap1 signaling pathway, Neuroactive ligand-receptor interaction |