Gene Symbol | GRIK3 |
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Entrez Gene | 2899 |
Alt Symbol | EAA5, GLR7, GLUR7, GluK3, GluR7a |
Species | Human |
Gene Type | protein-coding |
Description | glutamate receptor, ionotropic, kainate 3 |
Other Description | dJ1090M5.1 (glutamate receptor, ionotropic, kainate 3 (GLUR7))|excitatory amino acid receptor 5|gluR-7|glutamate receptor 7|glutamate receptor ionotropic, kainate 3 |
Swissprots | A9Z1Z8 Q13003 Q16136 Q13004 B1AMS6 |
Accessions | AAB30157 AAC50421 CAC40655 CAC40656 CAC40657 EAX07350 EAX07351 Q13003 AJ249210 CAC80548 AJ299451 CAC44965 AW898512 BC156721 AAI56722 BG057125 BG818719 BI544689 BQ446793 DR003075 DT217951 U16127 AAB60407 XM_011541294 XP_011539596 XM_011541295 XP_011539597 NM_000831 NP_000822 |
Function | Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. |
Top Pathways | Glutamatergic synapse, Neuroactive ligand-receptor interaction |
GluR-7 CRISPR/Cas9 KO Plasmid (h) - sc-408733 from Santa Cruz Biotechnology
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GluR-7 HDR Plasmid (h) - sc-408733-HDR from Santa Cruz Biotechnology
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GluR-7 Double Nickase Plasmid (h) - sc-408733-NIC from Santa Cruz Biotechnology
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GluR-7 Double Nickase Plasmid (h2) - sc-408733-NIC-2 from Santa Cruz Biotechnology
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GluR-7 CRISPR Activation Plasmid (h) - sc-408733-ACT from Santa Cruz Biotechnology
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GluR-7 CRISPR Activation Plasmid (h2) - sc-408733-ACT-2 from Santa Cruz Biotechnology
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GluR-7 Lentiviral Activation Particles (h) - sc-408733-LAC from Santa Cruz Biotechnology
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GluR-7 Lentiviral Activation Particles (h2) - sc-408733-LAC-2 from Santa Cruz Biotechnology
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GluR-7 siRNA (h) - sc-42489 from Santa Cruz Biotechnology
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GluR-7 shRNA Plasmid (h) - sc-42489-SH from Santa Cruz Biotechnology
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GluR-7 shRNA (h) Lentiviral Particles - sc-42489-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU137711 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1825 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1825 from Sigma-Aldrich
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GRIK3 siRNA (Human) - CRH1953 from Cohesion Biosciences
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GluR7/GRIK3 RNAi - H00002899-R01 from Novus Biologicals
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GRIK3 - MBS8231856 from MyBioSource
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shRNA set against Human GRIK3 (NM_000831.3) - SHH307850 from Creative biogene
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shRNA set against Human GRIK3(NM_000831.3) - SHH104433 from Creative biogene
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Human GRIK3 siRNA - orb262455 from Biorbyt
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GRIK3 shRNA Plasmid (Human) - CHH1953 from Cohesion Biosciences
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GRIK3 miRNA 3'UTR clone - MiUTR1H-04270 from Creative biogene
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