| Gene Symbol | HLA-DRA |
|---|---|
| Entrez Gene | 3122 |
| Alt Symbol | HLA-DRA1, MLRW |
| Species | Human |
| Gene Type | protein-coding |
| Description | major histocompatibility complex, class II, DR alpha |
| Other Description | HLA class II histocompatibility antigen, DR alpha chain|MHC cell surface glycoprotein|MHC class II antigen DRA|histocompatibility antigen HLA-DR alpha |
| Swissprots | A2BET4 Q9TP70 Q861I2 Q30160 Q6IAZ1 P01903 |
| Accessions | AAA36301 AAA36302 AAO23887 AAV74559 AAV74560 AHW47918 AHW47935 AHW47952 AHW47969 CAA23783 CAA25076 CAB06609 CAP40292 CAP40293 EAX03629 EAX03630 EAX03631 P01903 AI492718 AK297032 BAG59560 AK301134 BAG62726 AK301190 BAH13427 AK301354 BAG62899 AK304429 BAG65256 AK310161 AK313123 BAG35943 BC032350 AAH32350 BC071659 AAH71659 BG548634 BM849755 CR457013 CAG33294 DQ891595 ABM82521 DQ894789 ABM85715 J00193 AAA36272 J00194 AAA36275 J00195 J00197 K01171 AAA59785 M35979 AAA36283 M60333 AAA59787 M60334 AAA59783 V00523 CAA23782 V00528 CAA23787 NM_019111 NP_061984 |
| Function | Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loa |
| Subcellular Location | Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single- pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation. |
| Top Pathways | Leishmaniasis, Influenza A, HTLV-I infection, Tuberculosis, Herpes simplex infection |