Gene Symbol | IRF2BP2 |
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Entrez Gene | 359948 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | interferon regulatory factor 2 binding protein 2 |
Other Description | IRF-2-binding protein 2|interferon regulatory factor 2-binding protein 2 |
Swissprots | B1AM35 Q8N351 Q7Z5L9 B1AM36 Q8WUH8 Q6P083 Q7Z5L8 |
Accessions | EAW69996 Q7Z5L9 AK054864 AK056930 AK300375 BAG62111 AK309579 AY278023 AAP78944 AY278024 AAP78945 BC020516 AAH20516 BC041989 BC053539 BC065759 AAH65759 BC160054 AAI60054 BE408503 CD640986 NM_001077397 NP_001070865 NM_182972 NP_892017 |
Function | Acts as a transcriptional corepressor in a IRF2- dependent manner; this repression is not mediated by histone deacetylase activities. Represses the NFAT1-dependent transactivation of NFAT-responsive promoters. Acts as a coactivator of VEGFA expression in cardiac and skeletal muscle. {ECO:0000269|PubMed:12799427, ECO:0000269|PubMed:20702774, ECO:0000269|PubMed:21576369}. |
Subcellular Location | Cytoplasm. Nucleus. |
IRF-2BP2 CRISPR/Cas9 KO Plasmid (h) - sc-406153 from Santa Cruz Biotechnology
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IRF-2BP2 HDR Plasmid (h) - sc-406153-HDR from Santa Cruz Biotechnology
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IRF-2BP2 Double Nickase Plasmid (h) - sc-406153-NIC from Santa Cruz Biotechnology
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IRF-2BP2 Double Nickase Plasmid (h2) - sc-406153-NIC-2 from Santa Cruz Biotechnology
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IRF-2BP2 CRISPR Activation Plasmid (h) - sc-406153-ACT from Santa Cruz Biotechnology
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IRF-2BP2 CRISPR Activation Plasmid (h2) - sc-406153-ACT-2 from Santa Cruz Biotechnology
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IRF-2BP2 Lentiviral Activation Particles (h) - sc-406153-LAC from Santa Cruz Biotechnology
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IRF-2BP2 Lentiviral Activation Particles (h2) - sc-406153-LAC-2 from Santa Cruz Biotechnology
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IRF-2BP2 siRNA (h) - sc-88031 from Santa Cruz Biotechnology
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IRF-2BP2 shRNA Plasmid (h) - sc-88031-SH from Santa Cruz Biotechnology
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IRF-2BP2 shRNA (h) Lentiviral Particles - sc-88031-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU155771 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10764 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10764 from Sigma-Aldrich
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IRF2BP2 siRNA (Human) - CRJ7599 from Cohesion Biosciences
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IRF2BP2 - MBS8215598 from MyBioSource
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shRNA set against Human IRF2BP2 (NM_182972.2) - SHH320593 from Creative biogene
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shRNA set against Human IRF2BP2(NM_182972.2) - SHL180732 from Creative biogene
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shRNA set against Human IRF2BP2(NM_001077397.1) - SHL180816 from Creative biogene
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IRF2BP2 shRNA Plasmid (Human) - CHJ7599 from Cohesion Biosciences
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IRF2BP2 miRNA 3'UTR clone - MiUTR1H-04992 from Creative biogene
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IRF2BP2 miRNA 3'UTR clone - MiUTR1H-04993 from Creative biogene
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