Gene Symbol | SMARCC1 |
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Entrez Gene | 6599 |
Alt Symbol | BAF155, CRACC1, Rsc8, SRG3, SWI3 |
Species | Human |
Gene Type | protein-coding |
Description | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 |
Other Description | BRG1-associated factor 155|SWI/SNF complex 155 kDa subunit|SWI/SNF complex subunit SMARCC1|SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1|chromatin remodeling complex BAF155 subunit|mammalian chromatin remodeling complex BRG1-associated factor 155 |
Swissprots | Q6P172 Q17RS0 Q92922 Q8IWH2 |
Accessions | EAW64831 EAW64832 Q92922 AK302412 BAG63721 AK302541 BAG63813 BC012101 BC021862 AAH21862 BC032564 AAH32564 BC039843 AAH39843 BC040242 BC050564 AAH50564 BC065253 AAH65253 BC113465 AAI13466 BC117213 AAI17214 BG474088 BM971095 EU832157 ACE87507 EU832251 ACE86821 U66615 AAC50693 XM_011534034 XP_011532336 XM_011534035 XP_011532337 NM_003074 NP_003065 |
Function | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). May stimulate the ATPase activity of the catalytic subunit of the complex. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron- specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post- mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is |
Subcellular Location | Nucleus. |
Tissue Specificity | Expressed in brain, heart, muscle, placenta, lung, liver, muscle, kidney and pancreas. |
BAF155 CRISPR/Cas9 KO Plasmid (h) - sc-400838 from Santa Cruz Biotechnology
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BAF155 HDR Plasmid (h) - sc-400838-HDR from Santa Cruz Biotechnology
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BAF155 Double Nickase Plasmid (h) - sc-400838-NIC from Santa Cruz Biotechnology
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BAF155 Double Nickase Plasmid (h2) - sc-400838-NIC-2 from Santa Cruz Biotechnology
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BAF155 CRISPR Activation Plasmid (h) - sc-400838-ACT from Santa Cruz Biotechnology
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BAF155 CRISPR Activation Plasmid (h2) - sc-400838-ACT-2 from Santa Cruz Biotechnology
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BAF155 Lentiviral Activation Particles (h) - sc-400838-LAC from Santa Cruz Biotechnology
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BAF155 Lentiviral Activation Particles (h2) - sc-400838-LAC-2 from Santa Cruz Biotechnology
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BAF155 siRNA (h) - sc-29780 from Santa Cruz Biotechnology
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BAF155 shRNA Plasmid (h) - sc-29780-SH from Santa Cruz Biotechnology
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BAF155 shRNA (h) Lentiviral Particles - sc-29780-V from Santa Cruz Biotechnology
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SMARCC1 RNAi - H00006599-R01 from Novus Biologicals
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MISSION® esiRNA - EHU064391 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19767 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19767 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11172 from Sigma-Aldrich
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SMARCC1 siRNA (Human) - CRH4483 from Cohesion Biosciences
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SMARCC1 - MBS8211063 from MyBioSource
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Human SMARCC1 siRNA - orb264985 from Biorbyt
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SMARCC1 shRNA Plasmid (Human) - CHH4483 from Cohesion Biosciences
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