Gene Symbol | PLA2G7 |
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Entrez Gene | 7941 |
Alt Symbol | LDL-PLA2, LP-PLA2, PAFAD, PAFAH |
Species | Human |
Gene Type | protein-coding |
Description | phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) |
Other Description | 1-alkyl-2-acetylglycerophosphocholine esterase|2-acetyl-1-alkylglycerophosphocholine esterase|LDL-PLA(2)|LDL-associated phospholipase A2|PAF 2-acylhydrolase|PAF acetylhydrolase|gVIIA-PLA2|group-VIIA phospholipase A2|lipoprotein-associated phospholipase A2|platelet-activating factor acetylhydrolase |
Swissprots | Q15692 Q5VTT1 A5HTT5 Q13093 Q8IVA2 |
Accessions | ABQ01234 EAX04301 EAX04302 Q13093 AK290381 BAF83070 AK294471 BAG57699 AK297066 BAG59587 BC025674 BC038452 AAH38452 BP326231 HQ448549 ADQ33028 U20157 AAC50126 U24577 AAB04170 XM_005249408 XP_005249465 XM_005249409 XP_005249466 NM_001168357 NP_001161829 NM_005084 NP_005075 |
Function | Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids. |
Subcellular Location | Secreted, extracellular space. |
Tissue Specificity | Plasma. |
Top Pathways | Ether lipid metabolism |
PAF acetylhydrolase CRISPR/Cas9 KO Plasmid (h) - sc-403594 from Santa Cruz Biotechnology
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PAF acetylhydrolase HDR Plasmid (h) - sc-403594-HDR from Santa Cruz Biotechnology
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PAF acetylhydrolase Double Nickase Plasmid (h) - sc-403594-NIC from Santa Cruz Biotechnology
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PAF acetylhydrolase Double Nickase Plasmid (h2) - sc-403594-NIC-2 from Santa Cruz Biotechnology
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PAF acetylhydrolase CRISPR Activation Plasmid (h) - sc-403594-ACT from Santa Cruz Biotechnology
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PAF acetylhydrolase CRISPR Activation Plasmid (h2) - sc-403594-ACT-2 from Santa Cruz Biotechnology
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PAF acetylhydrolase Lentiviral Activation Particles (h) - sc-403594-LAC from Santa Cruz Biotechnology
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PAF acetylhydrolase Lentiviral Activation Particles (h2) - sc-403594-LAC-2 from Santa Cruz Biotechnology
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PAF acetylhydrolase siRNA (h) - sc-39691 from Santa Cruz Biotechnology
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PAF acetylhydrolase shRNA Plasmid (h) - sc-39691-SH from Santa Cruz Biotechnology
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PAF acetylhydrolase shRNA (h) Lentiviral Particles - sc-39691-V from Santa Cruz Biotechnology
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PLA2G7/PAF-AH/Lp-PLA2 RNAi - H00007941-R01 from Novus Biologicals
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MISSION® esiRNA - EHU084991 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16902 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16902 from Sigma-Aldrich
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PLA2G7 siRNA (Human) - CRH5323 from Cohesion Biosciences
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shRNA set against Human PLA2G7 (NM_005084.3) - SHH376904 from Creative biogene
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Human PLA2G7 siRNA - orb265825 from Biorbyt
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PLA2G7 shRNA Plasmid (Human) - CHH5323 from Cohesion Biosciences
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PLA2G7 miRNA 3'UTR clone - MiUTR3H-04324 from Creative biogene
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