| Gene Symbol |
GARS
|
| Entrez Gene |
2617
|
| Alt Symbol |
CMT2D, DSMAV, GlyRS, HMN5, SMAD1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
glycyl-tRNA synthetase
|
| Other Description |
AP-4-A synthetase|Charcot-Marie-Tooth neuropathy 2D|Charcot-Marie-Tooth neuropathy, neuronal type, D|diadenosine tetraphosphate synthetase|glycine tRNA ligase|glycine--tRNA ligase
|
| Swissprots |
Q969Y1 B4DIA0 P41250 B3KQA2
|
| Accessions |
AAC71652 AAS00367 EAL24449 EAW93960 EAW93961 P41250 AA772440 AK074524 BAG51964 AK295490 BAG58412 AK310351 BC000065 BC007722 AAH07722 BC007755 AAH07755 D30658 BAA06338 DQ892773 ABM83699 DQ896021 ABM87020 U09510 AAA86443 U09587 AAA57001 XM_006715686 XP_006715749 NM_002047 NP_002038
|
| Function |
Catalyzes the attachment of glycine to tRNA(Gly). Is also able produce diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. {ECO:0000269|PubMed:19710017}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:9524218}. Mitochondrion {ECO:0000269|PubMed:9524218}.
|
| Tissue Specificity |
Widely expressed, including brain and spinal cord. {ECO:0000269|PubMed:12690580}.
|
| Top Pathways |
Aminoacyl-tRNA biosynthesis
|