Cyr61
| Gene Symbol | Cyr61 |
|---|---|
| Entrez Gene | 16007 |
| Alt Symbol | AI325051, CCN1, Igfbp10 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | cysteine rich protein 61 |
| Other Description | 3CH61|CCN family member 1|IBP-10|IGF-binding protein 10|IGFBP-10|cysteine-rich angiogenic inducer 61|insulin-like growth factor binding protein 10|insulin-like growth factor-binding protein 10|intermediate early|protein CYR61 |
| Swissprots | P18406 |
| Accessions | CAA40109 CAS92740 CBX51737 EDL11998 P18406 AK156723 BAE33819 AK159452 BAE35095 BC003205 BC066019 AAH66019 M32490 AAA37512 NM_010516 NP_034646 |
| Function | Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 (By similarity). CYR61-mediated gene regulation is dependent on heparin-binding (By similarity). Down- regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 (By similarity). Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-1/beta-5 and cell proliferation through integrin alpha-v/beta-3 (By similarity). {ECO:0000250}. |
| Subcellular Location | Secreted. |
| Tissue Specificity | Low in kidney, adrenal gland, testes, brain, and ovary, moderate in heart, uterus, and skeletal muscle, highest in lung. |
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