PNKP

Gene Symbol PNKP
Entrez Gene 11284
Alt Symbol AOA4, EIEE10, MCSZ, PNK
Species Human
Gene Type protein-coding
Description polynucleotide kinase 3'-phosphatase
Other Description DNA 5'-kinase/3'-phosphatase|Homo sapiens polynucleotide kinase 3'-phosphatase (PNKP)|bifunctional polynucleotide phosphatase/kinase
Swissprots Q9BUL2 Q96T60 Q9UKU8 Q9P1V2 Q9UNI0 Q9UNF8
Accessions AAF44716 AAK57340 AAM82170 EAW52565 EAW52566 EAW52567 Q96T60 AA640353 AF120499 AAD47379 AF125807 AAD50639 AF126486 AAD51135 BC002519 AAH02519 BC009339 BC013034 BC033822 AAH33822 BU541073 DQ890806 ABM81732 DQ893961 ABM84887 NM_007254 NP_009185
Function Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone. {ECO:0000269|PubMed:10446192}.
Subcellular Location Nucleus {ECO:0000269|PubMed:10446193}.
Tissue Specificity Expressed in many tissues with highest expression in spleen and testis, and lowest expression in small intestine (PubMed:10446192). Expressed in higher amount in pancreas, heart and kidney and at lower levels in brain, lung and liver (PubMed:10446193). {ECO:0000269|PubMed:10446192, ECO:0000269|PubMed:10446193}.

PNK CRISPR/Cas9 KO Plasmid (h) - sc-404266 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PNK HDR Plasmid (h) - sc-404266-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PNK Double Nickase Plasmid (h) - sc-404266-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PNK Double Nickase Plasmid (h2) - sc-404266-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PNK CRISPR Activation Plasmid (h) - sc-404266-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PNK CRISPR Activation Plasmid (h2) - sc-404266-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PNK Lentiviral Activation Particles (h) - sc-404266-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PNK Lentiviral Activation Particles (h2) - sc-404266-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PNK siRNA (h) - sc-44826 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PNK shRNA Plasmid (h) - sc-44826-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PNK shRNA (h) Lentiviral Particles - sc-44826-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU132321 from Sigma-Aldrich

Category siRNA

MISSION® Human Phosphatase - SIHP0428 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0427 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0429 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

CompoZr® Knockout ZFN Kit - CKOZFN17045 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17045 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

PNKP siRNA (Human) - CRH7739 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PNK RNAi - H00011284-R04 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

shRNA set against Human PNKP (NM_007254.3) - SHH378568 from Creative biogene

Category siRNA
Species Reactivities Human

PNKP shRNA Plasmid (Human) - CHH7739 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PNKP miRNA 3'UTR clone - MiUTR3H-07833 from Creative biogene

Species Reactivities Human
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