ELF4

Gene Symbol	ELF4
Entrez Gene	2000
Alt Symbol	ELFR, MEF
Species	Human
Gene Type	protein-coding
Description	E74-like factor 4 (ets domain transcription factor)
Other Description	ETS-related transcription factor Elf-4|myeloid Elf-1-like factor
Swissprots	Q99607 O60435 D3DTG1
Accessions	EAX11813 EAX11814 Q99607 AF000670 AAC17452 AK314972 BC017194 AAH17194 BC114355 BC114356 CD364651 CN314421 DN999740 DQ892234 ABM83160 DQ895435 ABM86361 U32645 AAB53693 XM_005262389 XP_005262446 XM_011531307 XP_011529609 XM_011531308 XP_011529610 NM_001127197 NP_001120669 NM_001421 NP_001412
Function	Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity). Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2 (By similarity). Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway. {ECO:0000250, ECO:0000269|PubMed:10207087, ECO:0000269|PubMed:14625302, ECO:0000269|PubMed:14976184, ECO:0000269|PubMed:19380490, ECO:0000269|PubMed:8895518, ECO:0000269|PubMed:9524226}.
Subcellular Location	Nucleus, PML body {ECO:0000269|PubMed:14976184}. Note=Accumulation into PML nuclear bodies is mediated by PML.
Tissue Specificity	Abundantly expressed in the placenta and in a variety of myeloid leukemia cell lines. Moderate levels of expression in heart, lung, spleen, thymus, peripheral blood lymphocytes, ovary and colon. Lower levels of expression in Jurkat T-cells and other T-cell lines and no expression in brain. {ECO:0000269|PubMed:8895518, ECO:0000269|PubMed:9524226}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ELF4 overexpression lysate - LY400550 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

ELF4 overexpression lysate - LY426701 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

ELF4 293 Cell Lysate - 400550 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

Elf4/MEF Overexpression Lysate (Native) - NBL1-10231 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Elf-4 (h2): 293T Lysate - sc-176225 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

ELF4 Over-expression Lysate Product - GWB-EF884B from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Elf4/MEF Overexpression Lysate (Native) - NBP2-11389 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Elf4/MEF Overexpression Lysate (Denatured) - H00002000-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Panoply™ Human ELF4 Knockdown Stable Cell Line - CSC-DC004856 from Creative biogene Category Cell Line Species Human

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