| Gene Symbol |
CALHM1
|
| Entrez Gene |
255022
|
| Alt Symbol |
FAM26C
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
calcium homeostasis modulator 1
|
| Other Description |
calcium homeostasis modulator protein 1|family with sequence similarity 26, member C
|
| Swissprots |
Q5W091 Q8IU99
|
| Accessions |
EAW49632 Q8IU99 BC036193 AAH36193 BC036208 AAH36208 JF432767 ADZ15984 NM_001001412 NP_001001412
|
| Function |
Pore-forming subunit of a voltage-gated ion channel required for sensory perception of sweet, bitter and umami tastes. Specifically present in type II taste bud cells, where it plays a central role in sweet, bitter and umami taste perception by inducing ATP release from the cell, ATP acting as a neurotransmitter to activate afferent neural gustatory pathways. Acts both as a voltage-gated and calcium-activated ion channel: mediates neuronal excitability in response to changes in extracellular Ca(2+) concentration. Has poor ion selectivity and forms a wide pore (around 14 Angstroms) that mediates permeation of Ca(2+), Na(+) and K(+), as well as permeation of monovalent anions. Acts as an activator of the ERK1 and ERK2 cascade. Triggers endoplasmic reticulum stress by reducing the calcium content of the endoplasmic reticulum. May indirectly control amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca(2+) dependent manner. {ECO:0000269|Pub
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Colocalizes with HSPA5 at the endoplasmic reticulum.
|
| Tissue Specificity |
Predominantly expressed in adult brain. Detected also in retinoic acid-differentiated SH-SY5Y cells. Specifically expressed in circumvallate taste bud cells. {ECO:0000269|PubMed:18585350, ECO:0000269|PubMed:19997627}.
|