| Gene Symbol |
GALR2
|
| Entrez Gene |
8811
|
| Alt Symbol |
GAL2-R, GALNR2, GALR-2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
galanin receptor 2
|
| Other Description |
galanin receptor type 2
|
| Swissprots |
A5JUU4 Q32MN8 O43603
|
| Accessions |
AAC18118 AAC36587 EAW89364 O43603 AF040630 AAC39634 AF080586 AAD08671 BC069130 AAH69130 BC074914 AAH74914 BC074915 AAH74915 BC109051 AAI09052 BC109052 AAI09053 BU631750 EF577401 ABQ52421 XM_011525427 XP_011523729 NM_003857 NP_003848
|
| Function |
Receptor for the hormone galanin and GALP. Receptor for the hormone spexin-1 (PubMed:24517231). The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)). {ECO:0000269|PubMed:24517231}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Expressed abundantly within the central nervous system in both hypothalamus and hippocampus. In peripheral tissues, the strongest expression was observed in heart, kidney, liver, and small intestine.
|
| Top Pathways |
Neuroactive ligand-receptor interaction
|