Gene Symbol | Hspb1 |
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Entrez Gene | 24471 |
Alt Symbol | Hsp25, Hsp27 |
Species | Rat |
Gene Type | protein-coding |
Description | heat shock protein B1 |
Other Description | HSP 27|heat shock 27 kDa protein 1|heat shock 27kDa protein 1|heat shock protein beta-1 |
Swissprots | P42930 Q63922 Q9QWA8 |
Accessions | AAB29536 EDM13341 P42930 FM035762 FQ215417 FQ221491 FQ222013 FQ222462 M86389 AAA41353 NM_031970 NP_114176 |
Function | Involved in stress resistance and actin organization. |
Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles (By similarity). {ECO:0000250}. |
Tissue Specificity | Expressed in a variety of tissues. High levels in lung, adrenal, xiphoid, adipose tissue, heart and striated and smooth muscle, lower levels in the CNS. Adult levels are much higher in the slow-twitch soleus muscle than in the fast-twitch rectus femoris and extensor digitorum muscles. {ECO:0000269|PubMed:8282729}. |
Top Pathways | VEGF signaling pathway, MAPK signaling pathway, Amoebiasis, Epstein-Barr virus infection |
HSP 27 siRNA (r) - sc-270545 from Santa Cruz Biotechnology
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HSP 27 shRNA Plasmid (r) - sc-270545-SH from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN55246 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND55246 from Sigma-Aldrich
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HSPB1 siRNA (Rat) - CRR0157 from Cohesion Biosciences
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HSPB1 - MBS8204649 from MyBioSource
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shRNA set against Rat HSPB1 (NM_031970.3) - SHH315653 from Creative biogene
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shRNA set against Rat Hspb1(NM_031970.3) - SHH134435 from Creative biogene
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Rat HSPB1 siRNA - orb295006 from Biorbyt
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HSPB1 shRNA Plasmid (Rat) - CHR0157 from Cohesion Biosciences
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HSPB1 miRNA 3'UTR clone - MiUTR1R-02531 from Creative biogene
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