| Gene Symbol | SHO1 |
|---|---|
| Entrez Gene | 856854 |
| Alt Symbol | SSU81 |
| Species | Yeast |
| Gene Type | protein-coding |
| Description | osmosensor SHO1 |
| Other Description | - |
| Swissprots | D3DM24 P40073 E7LTJ6 E7KMS3 E7Q311 E7QE10 B3LRN4 C7GKW5 A6ZR73 B5VHP4 E7KBW4 |
| Accessions | DAA07778 P40073 NM_001179008 NP_011043 |
| Function | Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity. Detects changes in external osmolarity and activates PBS2 through the stimulation of STE11 and targets PBS2 to the plasma membrane. PBS2 activation leads to changes in glycerol production that helps to balance the intracellular and external osmotic pressures. Activates also HOG1 in response to heat stress and mediates resistance to oxidative stress. Involved in the regulation of the mating pathway. May be a receptor that feeds into the pseudohyphal growth pathway (By similarity). {ECO:0000250}. |
| Subcellular Location | Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Bud {ECO:0000250}. Bud neck {ECO:0000250}. Cell projection {ECO:0000250}. Note=Localizes at the tip of the mating projection during conjugation. {ECO:0000250}. |
| Top Pathways | MAPK signaling pathway - yeast |