| Gene Symbol | CFB |
|---|---|
| Entrez Gene | 629 |
| Alt Symbol | AHUS4, ARMD14, BF, BFD, CFAB, CFBD, FB, FBI12, GBG, H2-Bf, PBF2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | complement factor B |
| Other Description | B-factor, properdin|C3 proaccelerator|C3 proactivator|C3/C5 convertase|glycine-rich beta glycoprotein|glycine-rich beta-glycoprotein|properdin factor B |
| Swissprots | Q5JP67 Q53F89 Q5ST50 O15006 P00751 Q9BX92 Q96HX6 Q9BTF5 B0QZQ6 Q29944 |
| Accessions | AAA59625 AAB67977 AAN71991 AAQ13379 AAQ13380 AAQ13401 EAX03550 P00751 AF349679 AAK30167 AK130533 AK223400 BAD97120 AK304042 BAG64953 AL701961 BC004143 AAH04143 BC007990 AAH07990 BI258352 CD689714 DC368322 DQ892313 ABM83239 DQ895516 ABM86442 J00126 AAA36226 J00185 AAA36219 J00186 AAA36220 K01566 AAA36225 L15702 AAA16820 S67310 AAD13989 X00284 CAA25077 X72875 CAA51389 NM_001710 NP_001701 |
| Function | Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B- lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes. |
| Subcellular Location | Secreted. |
| Top Pathways | Complement and coagulation cascades, Staphylococcus aureus infection |