| Gene Symbol |
HAND2
|
| Entrez Gene |
9464
|
| Alt Symbol |
DHAND2, Hed, Thing2, bHLHa26, dHand
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
heart and neural crest derivatives expressed 2
|
| Other Description |
basic helix-loop-helix transcription factor HAND2|class A basic helix-loop-helix protein 26|deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2|heart- and neural crest derivatives-expressed protein 2
|
| Swissprots |
P97833 Q494T1 B6ECG9 O95301 O95300 P61296
|
| Accessions |
AAD13186 EAX04749 EAX04750 P61296 AF087940 AAD13185 AK122739 BAG53697 BC101406 AAI01407 BC101974 AAI01975 BC109383 AAI09384 BF313018 FJ226608 ACI42790 NM_021973 NP_068808
|
| Function |
Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981}.
|
| Tissue Specificity |
Heart.
|
![Western Blot: HAND2 Overexpression Lysate (Adult Normal) [NBP2-06491] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for HAND2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8252_HAND2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06491-img0001.jpg)