| Gene Symbol | Psma2 |
|---|---|
| Entrez Gene | 19166 |
| Alt Symbol | Lmpc3 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | proteasome (prosome, macropain) subunit, alpha type 2 |
| Other Description | macropain subunit C3|multicatalytic endopeptidase complex subunit C3|proteasome component C3|proteasome subunit alpha type-2 |
| Swissprots | Q6ZWV8 E9Q3A4 P49722 |
| Accessions | EDL32738 P49722 AF099733 AAD50623 AK012119 BAB28045 AK012990 BAB28582 AK035578 BAC29110 AK136115 BAE22828 AK151883 BAE30769 AK152862 BAE31553 AK154011 BAE32314 AK167752 BAE39787 AK209655 BC026768 AAH26768 BU755659 CJ052982 X70303 CAA49782 NM_008944 NP_032970 |
| Function | The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. PSMA2 may have a potential regulatory effect on another component(s) of the proteasome complex through tyrosine phosphorylation. {ECO:0000269|PubMed:22341445}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:22078707}. Nucleus {ECO:0000269|PubMed:22078707}. Cytoplasm, P-body {ECO:0000269|PubMed:22078707}. Note=Colocalizes with TRIM5 in the cytoplasmic bodies. |
| Tissue Specificity | Detected in liver (at protein level). {ECO:0000269|PubMed:22341445}. |
| Top Pathways | Proteasome |