| Gene Symbol | Pla2g5 |
|---|---|
| Entrez Gene | 18784 |
| Alt Symbol | PLA2, sPLA2 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | phospholipase A2, group V |
| Other Description | PLA2-10|calcium-dependent phospholipase A2|group V phospholipase A2|phosphatidylcholine 2-acylhydrolase 5 |
| Swissprots | P97391 Q9QZU6 |
| Accessions | EDL13279 EDL13280 EDL13281 EDL13282 P97391 AF162713 AAD45807 AK090021 BAC41050 AK157266 BAE34019 AK161336 BAE36332 BC030899 AAH30899 BY012884 BY015217 CK384107 U66873 AAC53038 XM_006538658 XP_006538721 XM_011250208 XP_011248510 NM_001122954 NP_001116426 NM_011110 NP_035240 |
| Function | PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. This isozyme hydrolyzes L- alpha-palmitoyl-2-oleoyl phosphatidylcholine more efficiently than L-alpha-1-palmitoyl-2-arachidonyl phosphatidylcholine, L-alpha-1- palmitoyl-2-arachidonyl phosphatidylethanolamine or L-alpha-1- stearoyl-2-arachidonyl phosphatidylinositol (By similarity). {ECO:0000250}. |
| Subcellular Location | Secreted {ECO:0000269|PubMed:10531350}. Membrane {ECO:0000269|PubMed:10531350}. Note=Also associated with various membranous organelles including the Golgi apparatus, nuclear envelope, and plasma membrane. |
| Top Pathways | Vascular smooth muscle contraction, Pancreatic secretion, Fat digestion and absorption, Ether lipid metabolism, Glycerophospholipid metabolism |