| Gene Symbol | MYD88 |
|---|---|
| Entrez Gene | 444881 |
| Alt Symbol | - |
| Species | Bovine |
| Gene Type | protein-coding |
| Description | myeloid differentiation primary response 88 |
| Other Description | myeloid differentiation factor 88|myeloid differentiation primary response gene (88)|myeloid differentiation primary response gene 88|myeloid differentiation primary response protein MyD88 |
| Swissprots | Q599T9 Q49BZ6 Q49CF6 Q6GV22 |
| Accessions | DAA17130 Q599T9 AJ853453 CAH68521 AY634627 AAT48485 AY934808 AAY16578 AY937381 AAY22119 BC102851 AAI02852 XM_005222379 XP_005222436 XR_814359 NM_001014382 NP_001014404 |
| Function | Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine. {ECO:0000269|PubMed:17936907, ECO:0000269|PubMed:18760477}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. |
| Top Pathways | Herpes simplex infection, Legionellosis, Tuberculosis, Pertussis, Salmonella infection |
Recombinant Bovine Myeloid differentiation primary response protein MyD88(MYD88) - CSB-YP685436BO CSB-EP685436BO CSB-BP685436BO CSB-MP685436BO from Cusabio
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Myeloid differentiation primary response protein MyD88 (MYD88), Recombinant Protein - MBS1446127 from MyBioSource
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