| Gene Symbol |
MYD88
|
| Entrez Gene |
444881
|
| Alt Symbol |
-
|
| Species |
Bovine
|
| Gene Type |
protein-coding
|
| Description |
myeloid differentiation primary response 88
|
| Other Description |
myeloid differentiation factor 88|myeloid differentiation primary response gene (88)|myeloid differentiation primary response gene 88|myeloid differentiation primary response protein MyD88
|
| Swissprots |
Q599T9 Q49BZ6 Q49CF6 Q6GV22
|
| Accessions |
DAA17130 Q599T9 AJ853453 CAH68521 AY634627 AAT48485 AY934808 AAY16578 AY937381 AAY22119 BC102851 AAI02852 XM_005222379 XP_005222436 XR_814359 NM_001014382 NP_001014404
|
| Function |
Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine. {ECO:0000269|PubMed:17936907, ECO:0000269|PubMed:18760477}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}.
|
| Top Pathways |
Herpes simplex infection, Legionellosis, Tuberculosis, Pertussis, Salmonella infection
|