| Gene Symbol | NDUFS2 |
|---|---|
| Entrez Gene | 4720 |
| Alt Symbol | CI-49 |
| Species | Human |
| Gene Type | protein-coding |
| Description | NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) |
| Other Description | CI-49kD|NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial|NADH-ubiquinone oxidoreductase 49 kDa subunit|NADH-ubiquinone oxidoreductase NDUFS2 subunit|complex 1, mitochondrial respiratory chain, 49-KD subunit|complex I 49kDa subunit|complex I-49kD |
| Swissprots | D3DVG7 Q9UEV3 Q969P3 O75306 Q5VTW0 J3KPM7 |
| Accessions | AAG13808 AAG13809 EAW52625 EAW52626 O75306 AF013160 AAC34362 AF050640 AAC27453 AK222618 BAD96338 AK301641 BAH13528 AK309871 AK314807 AK315977 BAH14348 BC000170 AAH00170 BC001456 AAH01456 BC008868 AAH08868 CA312786 DQ894087 ABM85013 Z36812 XM_005245208 XP_005245265 XM_005245209 XP_005245266 NM_001166159 NP_001159631 NM_004550 NP_004541 |
| Function | Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). {ECO:0000250}. |
| Subcellular Location | Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. |
| Top Pathways | Alzheimer's disease, Huntington's disease, Non-alcoholic fatty liver disease (NAFLD), Oxidative phosphorylation |