Gene Symbol | NDUFS2 |
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Entrez Gene | 4720 |
Alt Symbol | CI-49 |
Species | Human |
Gene Type | protein-coding |
Description | NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) |
Other Description | CI-49kD|NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial|NADH-ubiquinone oxidoreductase 49 kDa subunit|NADH-ubiquinone oxidoreductase NDUFS2 subunit|complex 1, mitochondrial respiratory chain, 49-KD subunit|complex I 49kDa subunit|complex I-49kD |
Swissprots | D3DVG7 Q9UEV3 Q969P3 O75306 Q5VTW0 J3KPM7 |
Accessions | AAG13808 AAG13809 EAW52625 EAW52626 O75306 AF013160 AAC34362 AF050640 AAC27453 AK222618 BAD96338 AK301641 BAH13528 AK309871 AK314807 AK315977 BAH14348 BC000170 AAH00170 BC001456 AAH01456 BC008868 AAH08868 CA312786 DQ894087 ABM85013 Z36812 XM_005245208 XP_005245265 XM_005245209 XP_005245266 NM_001166159 NP_001159631 NM_004550 NP_004541 |
Function | Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). {ECO:0000250}. |
Subcellular Location | Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. |
Top Pathways | Alzheimer's disease, Huntington's disease, Non-alcoholic fatty liver disease (NAFLD), Oxidative phosphorylation |
NDUFS2 CRISPR/Cas9 KO Plasmid (h) - sc-408140 from Santa Cruz Biotechnology
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NDUFS2 HDR Plasmid (h) - sc-408140-HDR from Santa Cruz Biotechnology
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NDUFS2 Double Nickase Plasmid (h) - sc-408140-NIC from Santa Cruz Biotechnology
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NDUFS2 Double Nickase Plasmid (h2) - sc-408140-NIC-2 from Santa Cruz Biotechnology
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NDUFS2 CRISPR Activation Plasmid (h) - sc-408140-ACT from Santa Cruz Biotechnology
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NDUFS2 CRISPR Activation Plasmid (h2) - sc-408140-ACT-2 from Santa Cruz Biotechnology
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NDUFS2 Lentiviral Activation Particles (h) - sc-408140-LAC from Santa Cruz Biotechnology
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NDUFS2 Lentiviral Activation Particles (h2) - sc-408140-LAC-2 from Santa Cruz Biotechnology
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NDUFS2 siRNA (h) - sc-78903 from Santa Cruz Biotechnology
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NDUFS2 shRNA Plasmid (h) - sc-78903-SH from Santa Cruz Biotechnology
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NDUFS2 shRNA (h) Lentiviral Particles - sc-78903-V from Santa Cruz Biotechnology
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NDUFS2 RNAi - H00004720-R01 from Novus Biologicals
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MISSION® esiRNA - EHU047141 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15167 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15167 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00690 from Sigma-Aldrich
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NDUFS2 siRNA (Human) - CRH3134 from Cohesion Biosciences
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NDUFS2 shRNA Plasmid (Human) - CHH3134 from Cohesion Biosciences
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