| Gene Symbol | FKBP5 |
|---|---|
| Entrez Gene | 2289 |
| Alt Symbol | AIG6, FKBP51, FKBP54, P54, PPIase, Ptg-10 |
| Species | Human |
| Gene Type | protein-coding |
| Description | FK506 binding protein 5 |
| Other Description | 51 kDa FK506-binding protein|51 kDa FKBP|54 kDa progesterone receptor-associated immunophilin|FF1 antigen|FKBP-51|HSP90-binding immunophilin|PPIase FKBP5|T-cell FK506-binding protein|androgen-regulated protein 6|peptidyl-prolyl cis-trans isomerase FKBP5|peptidylprolyl cis-trans isomerase|rotamase |
| Swissprots | Q13451 F5H7R1 Q59EB8 Q5TGM6 |
| Accessions | EAX03841 EAX03842 Q13451 AB209893 BAD93130 AF194172 AAL54872 AK222807 BAD96527 AK302704 BAH13784 AK303356 BAH13948 AK312422 BAG35332 AL122066 AM393744 CAL38619 AW182642 BC042605 AAH42605 BC111050 AAI11051 BX647390 DB066174 U42031 AAA86245 U71321 AAC51189 X97300 NM_001145775 NP_001139247 NM_001145776 NP_001139248 NM_001145777 NP_001139249 NM_004117 NP_004108 |
| Function | Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded. |
| Subcellular Location | Cytoplasm. Nucleus. |
| Tissue Specificity | Widely expressed, enriched in testis compared to other tissues. |
| Top Pathways | Estrogen signaling pathway |