LIN28A

Gene Symbol	LIN28A
Entrez Gene	79727
Alt Symbol	CSDD1, LIN-28, LIN28, ZCCHC1, lin-28A
Species	Human
Gene Type	protein-coding
Description	lin-28 homolog A (C. elegans)
Other Description	RNA-binding protein LIN-28|protein lin-28 homolog A|zinc finger CCHC domain-containing protein 1|zinc finger, CCHC domain containing 1
Swissprots	Q9H9Z2
Accessions	CAE90433 EAX07814 EAX07815 Q9H9Z2 AF521099 AAM77751 AK022519 BAB14075 BC028566 AAH28566 DQ893398 ABM84324 DQ896719 ABM87718 XM_011542148 XP_011540450 NM_024674 NP_078950
Function	Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (By similarity). Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let- 7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre- let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells. In contrast, LIN28A down-regulation in neur
Subcellular Location	Cytoplasm. Nucleus, nucleolus. Note=Nucleolar localization observed in 10-15% of the nuclei in differentiated myotubes (By similarity). Shuttles between the cytoplasm and the nucleus. Localizes to cytoplasmic processing bodies and stress granules. {ECO:0000250}.
Tissue Specificity	Expressed in embryonic stem cells (ES cells), placenta and testis. {ECO:0000269|PubMed:14688391, ECO:0000269|PubMed:15614775, ECO:0000269|PubMed:15722555}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse LIN28A / LIN28 ELISA Kit (Sandwich ELISA) - LS-F6886 from LifeSpan Bioscience Category ELISA Kit Prices $810.00 Sizes 1 plate Sensitivity 0.049 ng/ml Range 0.156-10 ng/ml

Lin28, Human, ELISA Kit - E01L0257 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Protein lin-28 homolog A, LIN28A, Human, ELISA Kit - E1540h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/ml

LIN28 (Human) IP-WB Antibody Pair - H00079727-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

lin-28 homolog (C. elegans) , ELISA Kit - MBS9323717 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Lin28, ELISA Kit - MBS750619 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Lin28, ELISA Kit - MBS750364 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Lin28, ELISA Kit - MBS751906 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Lin28, ELISA Kit - MBS752172 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Lin28, ELISA Kit - MBS749386 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Lin28, ELISA Kit - MBS746145 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Lin28, ELISA Kit - MBS754352 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Lin28, ELISA Kit - MBS754876 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Lin28, ELISA Kit - MBS750791 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Lin28, ELISA Kit - MBS753875 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Lin28, ELISA Kit - MBS748538 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Lin28, ELISA Kit - MBS754175 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for Lin-28 Homolog A (LIN28A) - SEM546Mu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.049ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Chicken LIN28A / LIN28 ELISA Kit (Custom ELISA) - LS-F17957 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Mouse LIN28A / LIN28 ELISA Kit (Custom ELISA) - LS-F17956 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Human LIN28A / LIN28 ELISA Kit (Sandwich ELISA) - LS-F17955 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.089 ng/ml Range 0.156-10 ng/ml

LIN28A - EKH3600 from Nordic BioSite Sensitivity 0.094ng/ml Range 0.156-10ng/ml

LIN28A ELISA Kit (Human) (OKEH01106) - OKEH01106 from Aviva Systems Biology Category ELISA Kit Prices $420.00 Sizes 96 wells Sensitivity < 0.089 ng/mL Range 0.156 - 10 ng/mL

Custom Human Lin-28A ELISA - ELH-Lin28A-1 from RayBiotech Category ELISA Kit Prices $627.00, $1,128.60, $2,508.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Custom Human Lin-28A ELISA Kit - orb384642 from Biorbyt Category ELISA Kit Prices $1,411.00, $2,448.00, $5,321.00 Sizes 96 assays, 192 assays, 480 assays

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