| Gene Symbol | LIN28A |
|---|---|
| Entrez Gene | 79727 |
| Alt Symbol | CSDD1, LIN-28, LIN28, ZCCHC1, lin-28A |
| Species | Human |
| Gene Type | protein-coding |
| Description | lin-28 homolog A (C. elegans) |
| Other Description | RNA-binding protein LIN-28|protein lin-28 homolog A|zinc finger CCHC domain-containing protein 1|zinc finger, CCHC domain containing 1 |
| Swissprots | Q9H9Z2 |
| Accessions | CAE90433 EAX07814 EAX07815 Q9H9Z2 AF521099 AAM77751 AK022519 BAB14075 BC028566 AAH28566 DQ893398 ABM84324 DQ896719 ABM87718 XM_011542148 XP_011540450 NM_024674 NP_078950 |
| Function | Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (By similarity). Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let- 7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre- let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells. In contrast, LIN28A down-regulation in neur |
| Subcellular Location | Cytoplasm. Nucleus, nucleolus. Note=Nucleolar localization observed in 10-15% of the nuclei in differentiated myotubes (By similarity). Shuttles between the cytoplasm and the nucleus. Localizes to cytoplasmic processing bodies and stress granules. {ECO:0000250}. |
| Tissue Specificity | Expressed in embryonic stem cells (ES cells), placenta and testis. {ECO:0000269|PubMed:14688391, ECO:0000269|PubMed:15614775, ECO:0000269|PubMed:15722555}. |