LIN28A

Gene Symbol	LIN28A
Entrez Gene	79727
Alt Symbol	CSDD1, LIN-28, LIN28, ZCCHC1, lin-28A
Species	Human
Gene Type	protein-coding
Description	lin-28 homolog A (C. elegans)
Other Description	RNA-binding protein LIN-28|protein lin-28 homolog A|zinc finger CCHC domain-containing protein 1|zinc finger, CCHC domain containing 1
Swissprots	Q9H9Z2
Accessions	CAE90433 EAX07814 EAX07815 Q9H9Z2 AF521099 AAM77751 AK022519 BAB14075 BC028566 AAH28566 DQ893398 ABM84324 DQ896719 ABM87718 XM_011542148 XP_011540450 NM_024674 NP_078950
Function	Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (By similarity). Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let- 7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre- let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells. In contrast, LIN28A down-regulation in neur
Subcellular Location	Cytoplasm. Nucleus, nucleolus. Note=Nucleolar localization observed in 10-15% of the nuclei in differentiated myotubes (By similarity). Shuttles between the cytoplasm and the nucleus. Localizes to cytoplasmic processing bodies and stress granules. {ECO:0000250}.
Tissue Specificity	Expressed in embryonic stem cells (ES cells), placenta and testis. {ECO:0000269|PubMed:14688391, ECO:0000269|PubMed:15614775, ECO:0000269|PubMed:15722555}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Lin28 protein fragment - ab107950 from Abcam Category Protein Prices $239.00 Sizes 25 µg Source E. coli Species Human

Human Lin28 peptide - ab64578 from Abcam Category Peptide

Human Lin28 protein fragment - ab89225 from Abcam Category Protein Source E. coli Species Human

LIN28A / LIN28 Antibody Blocking Peptide - LS-E833 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LIN28A / LIN28 Antibody Blocking Peptide - LS-E12225 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LIN28A / LIN28 Antibody Blocking Peptide - LS-E30864 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

LIN28A / LIN28 Antibody Blocking Peptide - LS-E7473 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LIN-28A Peptide - NBP1-60172 from Novus Biologicals Category Peptide Prices $249.00 Sizes 250 µg

Recombinant Human LIN-28A Protein - NBP1-30275 from Novus Biologicals Category Protein Prices $349.00 Sizes 50 µg Source E.coli Species Human

Recombinant Human LIN-28A Protein - P6110 from Novus Biologicals Category Protein Prices $359.00 Sizes 25 µg Species Human

LIN-28A Recombinant Protein - H00079727-P01 from Novus Biologicals Category Protein Species Human

LIN-28A Peptide - NBP1-77383PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

LIN28A-Antibody-Center-Blocking-peptide - BP11206c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Phospho-LIN28S134-Antibody-Blocking-peptide - BP3732a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

Lin28-TAT recombinant protein - GTX53840 from GeneTex Category Protein Prices $199.00 Sizes 25 μg Source E. Coli

LIN28 Protein (OPPA02194) - OPPA02194 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source E. Coli

Human LIN28 protein - orb81197 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Species Human

Lin28 Blocking Peptide - 33R-10628 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

Lin28 protein (His tag) - 80R-1211 from Fitzgerald Category Protein Prices $340.00 Sizes 50 µg Source E.coli

LIN28 (42-209, His-tag) - AR09295PU-L from Acris Antibodies Category Protein Prices $1,020.00 Sizes 250 µg Source E. coli Species Human

LIN28 (42-209, His-tag) - AR09295PU-N from Acris Antibodies Category Protein Prices $420.00 Sizes 50 µg Source E. coli Species Human

LIN28 TAT Fusion Protein - AR20003PU-N from Acris Antibodies Category Protein Prices $235.00 Sizes 25 µg Source E. coli Species Human

LIN28 TAT Fusion Protein - AR20003PU-S from Acris Antibodies Category Protein Prices $135.00 Sizes 5 µg Source E. coli Species Human

LIN28 - H00079727-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

LIN28 - P6110 from Acris Antibodies Category Protein Prices $370.00 Sizes 25 µg Species Human

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