| Gene Symbol | rnf8 |
|---|---|
| Entrez Gene | 404050 |
| Alt Symbol | fc66f09, wu:fc66f09, zgc:55936, zgc:77313 |
| Species | Zebrafish |
| Gene Type | protein-coding |
| Description | ring finger protein 8, E3 ubiquitin protein ligase |
| Other Description | E3 ubiquitin-protein ligase RNF8|ring finger protein (C3HC4 type) 8 |
| Swissprots | Q6P0F2 Q803C1 |
| Accessions | Q803C1 BC044545 AAH44545 BC065643 AAH65643 NM_205553 NP_991116 NM_205766 NP_991329 |
| Function | E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'- linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated mdc1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of tp53bp1 and brca1 ionizing radiation-induced foci (IRIF). H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains, leading to degradation of substrate proteins. In addition to its function in damage signaling, also plays a role in higher-order |
| Subcellular Location | Nucleus {ECO:0000250}. Note=Following DNA double-strand breaks, recruited to the sites of damage. {ECO:0000250}. |