Gene Symbol | PCBD1 |
---|---|
Entrez Gene | 5092 |
Alt Symbol | DCOH, PCBD, PCD, PHS |
Species | Human |
Gene Type | protein-coding |
Description | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha |
Other Description | 4-alpha-hydroxy-tetrahydropterin dehydratase|6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1)|dimerizing cofactor for HNF1|phenylalanine hydroxylase-stimulating protein|pterin-4-alpha-carbinolamine dehydratase |
Swissprots | P61457 |
Accessions | AAA35670 AAA35671 AAA35672 AAA69662 EAW54416 EAW54417 P61457 AA397961 AA736613 AF082858 AAD25732 BC006324 AAH06324 BI548743 BM724638 BQ685076 BQ897536 CR542194 CAG46991 L41559 AAA69663 M83742 XM_005269877 XP_005269934 NM_000281 NP_000272 NM_001289797 NP_001276726 |
Function | Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity. |
Subcellular Location | Cytoplasm. Nucleus. Note=Cytoplasmic and/or nuclear. |
PCBD1 CRISPR/Cas9 KO Plasmid (h) - sc-417347 from Santa Cruz Biotechnology
|
||||||||
PCBD1 HDR Plasmid (h) - sc-417347-HDR from Santa Cruz Biotechnology
|
||||||||
PCBD1 Double Nickase Plasmid (h) - sc-417347-NIC from Santa Cruz Biotechnology
|
||||||||
PCBD1 Double Nickase Plasmid (h2) - sc-417347-NIC-2 from Santa Cruz Biotechnology
|
||||||||
PCBD1 CRISPR Activation Plasmid (h) - sc-417347-ACT from Santa Cruz Biotechnology
|
||||||||
PCBD1 CRISPR Activation Plasmid (h2) - sc-417347-ACT-2 from Santa Cruz Biotechnology
|
||||||||
PCBD1 Lentiviral Activation Particles (h) - sc-417347-LAC from Santa Cruz Biotechnology
|
||||||||
PCBD1 Lentiviral Activation Particles (h2) - sc-417347-LAC-2 from Santa Cruz Biotechnology
|
||||||||
PCBD1 siRNA (h) - sc-90559 from Santa Cruz Biotechnology
|
||||||||
PCBD1 shRNA Plasmid (h) - sc-90559-SH from Santa Cruz Biotechnology
|
||||||||
PCBD1 shRNA (h) Lentiviral Particles - sc-90559-V from Santa Cruz Biotechnology
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN16390 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16390 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR03709 from Sigma-Aldrich
|
||||||||
PCBD1 siRNA (Human) - CRH3386 from Cohesion Biosciences
|
||||||||
PCBD1 RNAi - H00005092-R01 from Novus Biologicals
|
||||||||
shRNA set against Human PCBD1 (NM_000281.2) - SHH371360 from Creative biogene
|
||||||||
shRNA set against Human PCBD1(NM_000281.2) - SHR090708 from Creative biogene
|
||||||||
PCBD1 shRNA Plasmid (Human) - CHH3386 from Cohesion Biosciences
|
||||||||
PCBD1 miRNA 3'UTR clone - MiUTR1H-07553 from Creative biogene
|