| Gene Symbol |
ENOX1
|
| Entrez Gene |
55068
|
| Alt Symbol |
CNOX, PIG38, bA64J21.1, cCNOX
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ecto-NOX disulfide-thiol exchanger 1
|
| Other Description |
candidate growth-related and time keeping constitutive hydroquinone (NADH) oxidase|candidate growth-related and time keeping constitutive hydroquinone [NADH] oxidase|cell proliferation-inducing gene 38 protein|constitutive Ecto-NOX
|
| Swissprots |
Q2TU81 Q9NWE0 B7Z5K1 A6NMH9 Q8TC92 Q5VT11 A4GU15
|
| Accessions |
EAX08691 EAX08692 EAX08693 EAX08694 EAX08695 Q8TC92 AK000956 BAA91442 AK055477 AK299053 BAH12937 AY513282 AAT08035 BC024178 AAH24178 BC068521 BM551661 BM834061 DA512678 DA779748 DB058776 DB092904 EF432052 ABO28524 XM_005266439 XP_005266496 XM_006719841 XP_006719904 XM_011535125 XP_011533427 XM_011535126 XP_011533428 XM_011535127 XP_011533429 XM_011535128 XP_011533430 XM_011535129 XP_011533431 XM_011535130 XP_011533432 XM_011535131 XP_011533433 XM_011535132 XP_011533434 NM_001127615 NP_001121087 NM_001242863 NP_001229792 NM_017993 NP_060463
|
| Function |
Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 24 minutes and play a role in control of the ultradian cellular biological clock. {ECO:0000269|PubMed:11360993, ECO:0000269|PubMed:12565167, ECO:0000269|PubMed:17027975, ECO:0000269|PubMed:19055324}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:11360993}. Secreted, extracellular space {ECO:0000269|PubMed:11360993}. Note=Extracellular and plasma membrane-associated.
|
| Tissue Specificity |
Expressed in lymphocyte cells, breast and breast cancer (at protein level). Found in the sera of cancer patients with a wide variety of cancers including breast, prostate, lung and ovarian cancers, leukemias, and lymphomas. Found also in the serum of healthy volunteers or patients with disorders other than cancer. Probably shed into serum by cancer cells.
|
![Western Blot: CNOX Overexpression Lysate (Adult Normal) [NBP2-11368] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CNOX.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2417_CNOX%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-11368-img0001.jpg)