COPS2

Gene Symbol	COPS2
Entrez Gene	9318
Alt Symbol	ALIEN, CSN2, SGN2, TRIP15
Species	Human
Gene Type	protein-coding
Description	COP9 signalosome subunit 2
Other Description	COP9 constitutive photomorphogenic homolog subunit 2|COP9 signalosome complex subunit 2|JAB1-containing signalosome subunit 2|TR-interacting protein 15|TRIP-15|alien homolog|signalosome subunit 2|thyroid receptor interacting protein 15|thyroid receptor-interacting protein 15
Swissprots	Q6FGP4 Q9UNI2 Q9BY54 P61201
Accessions	EAW77364 EAW77365 EAW77366 P61201 AB209799 BAD93036 AF084260 AAC34122 AF100762 AAD43026 AF120268 AAD30269 AF212227 AAK26250 AK222590 BAD96310 AK295598 BAG58487 AK312643 BAG35527 BC012629 AAH12629 BM667648 BX648602 CN281648 CN287009 CR542063 CAG46860 DB059510 EU446744 ABZ92273 EU831466 ACE87153 EU831553 ACE86472 L40388 AAC41734 NM_001143887 NP_001137359 NM_004236 NP_004227
Function	Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN- dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}.
Subcellular Location	Cytoplasm. Nucleus.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse/Human/Rat COPS2 / TRIP15 / ALIEN ELISA Kit (Cell-Based ELISA) - LS-F3140 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate

Beta-casein (CSN2), Human, ELISA Kit - E01B0896 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Beta-casein, CSN2, Human, ELISA Kit - E13952h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

COP9 signalosome complex subunit 2 (COPS2), Human, ELISA Kit - E01C1937 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

COP9 signalosome complex subunit 2 (COPS2), ELISA Kit - MBS7200768 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

COP9 signalosome complex subunit 2 (COPS2), ELISA Kit - MBS7234575 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

COP9 signalosome complex subunit 2 (COPS2), ELISA Kit - MBS7250723 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

COP9 signalosome complex subunit 2 (COPS2), ELISA Kit - MBS7252518 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

COP9 signalosome complex subunit 2 (COPS2), ELISA Kit - MBS7235897 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

COP9 signalosome complex subunit 2 (COPS2), ELISA Kit - MBS7243631 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

COP9 signalosome complex subunit 2 (COPS2), ELISA Kit - MBS7238018 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

COP9 signalosome complex subunit 2 (COPS2), ELISA Kit - MBS7211141 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

COP9 signalosome complex subunit 2 (COPS2), ELISA Kit - MBS7221439 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

COP9 signalosome complex subunit 2 (COPS2), ELISA Kit - MBS7219910 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

COP9 signalosome complex subunit 2 (COPS2), ELISA Kit - MBS7203787 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

COP9 signalosome complex subunit 2 (COPS2), ELISA Kit - MBS7237590 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

COPS2 Colorimetric Cell-Based ELISA - CB5934 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Casein Beta (CSN2), Human, ELISA Kit - DL-CSN2-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 78-5,000 ng/mL

COPS2 ELISA Kit - DEIA-XYA448 from Creative Diagnostics Category ELISA Kit

Human CSN2 ELISA Kit - orb369844 from Biorbyt Category ELISA Kit Prices $553.00, $621.00 Sizes 48 test, 96 test Range Detection Range: 78.125-5000ng/mL Detection low threshold: 27ng/mL

Human CSN2 ELISA Kit - abx576260 from Abbexa Category ELISA Kit Sensitivity 27 ng/ml Range 78.125 ng/ml - 5000 ng/ml

CSN2 - EKH3096 from Nordic BioSite Sensitivity 0.094ng/ml Range 0.156-10ng/ml

Human CSN2 ELISA Kit - E006799 from Biobool Category ELISA Kit Sensitivity 6.25ug/ml

Human COPS2 ELISA Kit - E080284 from Biobool Category ELISA Kit

anti-COPS2 / TRIP15 antibody - ARG55828 from Arigo Biolaboratories Category ELISA Kit

Search more