COPS2

Gene Symbol	COPS2
Entrez Gene	9318
Alt Symbol	ALIEN, CSN2, SGN2, TRIP15
Species	Human
Gene Type	protein-coding
Description	COP9 signalosome subunit 2
Other Description	COP9 constitutive photomorphogenic homolog subunit 2|COP9 signalosome complex subunit 2|JAB1-containing signalosome subunit 2|TR-interacting protein 15|TRIP-15|alien homolog|signalosome subunit 2|thyroid receptor interacting protein 15|thyroid receptor-interacting protein 15
Swissprots	Q6FGP4 Q9UNI2 Q9BY54 P61201
Accessions	EAW77364 EAW77365 EAW77366 P61201 AB209799 BAD93036 AF084260 AAC34122 AF100762 AAD43026 AF120268 AAD30269 AF212227 AAK26250 AK222590 BAD96310 AK295598 BAG58487 AK312643 BAG35527 BC012629 AAH12629 BM667648 BX648602 CN281648 CN287009 CR542063 CAG46860 DB059510 EU446744 ABZ92273 EU831466 ACE87153 EU831553 ACE86472 L40388 AAC41734 NM_001143887 NP_001137359 NM_004236 NP_004227
Function	Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN- dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}.
Subcellular Location	Cytoplasm. Nucleus.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-COPS2-cDNA-Clone - DC03478 from Abgent, a WuXi AppTec company Prices $598.05 Sizes 10 µg Species Human Accession BC012629

COPS2 - MBS1274067 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC012629

Human COPS2 cDNA clone(NM_001143887.1) - CDFH004082 from Creative Biomart Species Human Accession NM_001143887.1

Human COPS2 ORF Clone(NM_004236.3) - CDCL159454 from Creative Biomart Species Human Accession NM_004236.3

Human COPS2 ORF Clone(NM_001143887.1) - CDCL159455 from Creative Biomart Species Human Accession NM_001143887.1

Human COPS2 ORF Clone(NM_001143887.1) - CDCL159456 from Creative Biomart Species Human Accession NM_001143887.1

Human COPS2 ORF Clone(NM_001143887.1) - CDCR351878 from Creative Biomart Species Human Accession NM_001143887.1

Human COPS2 ORF Clone(NM_001143887.1) - CDCR351879 from Creative Biomart Species Human Accession NM_001143887.1

Human TRIP15/COPS2 transcript variant 1 Gene ORF cDNA clone in cloning vector - HG13676-G from Sino Biological Species Human

Human TRIP15/COPS2 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-His tag - HG13676-CH from Sino Biological Species Human

Human TRIP15/COPS2 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG13676-ACG from Sino Biological Species Human

Human TRIP15/COPS2 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG13676-NY from Sino Biological Species Human

Human TRIP15/COPS2 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG13676-ACR from Sino Biological Species Human

Human TRIP15/COPS2 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG13676-ANR from Sino Biological Species Human

Human TRIP15/COPS2 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG13676-NF from Sino Biological Species Human

Human TRIP15/COPS2 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG13676-NM from Sino Biological Species Human

Human TRIP15/COPS2 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG13676-CF from Sino Biological Species Human

Human TRIP15/COPS2 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG13676-CM from Sino Biological Species Human

Human TRIP15/COPS2 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-His tag - HG13676-NH from Sino Biological Species Human

Human TRIP15/COPS2 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG13676-CY from Sino Biological Species Human

Human TRIP15/COPS2 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG13676-ANG from Sino Biological Species Human

Human TRIP15/COPS2 transcript variant 1 Gene ORF cDNA clone expression plasmid - HG13676-UT from Sino Biological Species Human

Human CSN2 ORF clone(NM_004236.3) - CDCL183745 from Creative biogene Species Human

Human COPS2 ORF clone (NM_001143887.1) - CDCR026804 from Creative biogene Species Human

Human COPS2 ORF Clone (BC012629) - CDCS408363 from Creative biogene Species Human Accession P61201

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