| Gene Symbol | Ppp1cb |
|---|---|
| Entrez Gene | 25594 |
| Alt Symbol | - |
| Species | Rat |
| Gene Type | protein-coding |
| Description | protein phosphatase 1, catalytic subunit, beta isozyme |
| Other Description | PP-1B|protein phosphatase 1, catalytic subunit, beta isoform|protein phosphatase-1a|serine/threonine-protein phosphatase PP1-beta catalytic subunit |
| Swissprots | P62142 |
| Accessions | EDM02880 EDM02881 P62142 BC062033 AAH62033 D90164 BAA14195 FQ212294 FQ217350 FQ226372 FQ227415 M58434 AAA41905 S78218 AAB34335 XM_008764505 XP_008762727 NM_013065 NP_037197 |
| Function | Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Highly mobile in cells and can be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles (By similarity). {ECO:0000250}. |
| Top Pathways | Amphetamine addiction, cGMP-PKG signaling pathway, Oxytocin signaling pathway, Inflammatory mediator regulation of TRP channels, cAMP signaling pathway |