MCF2

Gene Symbol MCF2
Entrez Gene 4168
Alt Symbol ARHGEF21, DBL
Species Human
Gene Type protein-coding
Description MCF.2 cell line derived transforming sequence
Other Description Oncogene MCF2 (oncogene DBL)|proto-oncogene DBL|proto-oncogene MCF-2
Swissprots B7Z869 E9PH77 Q9UJB3 Q5JYJ4 F5H091 P14919 Q5JYJ2 B7ZAV1 P10911 B7Z3Y5 Q8IUF4 Q8IUF3 Q5JYJ3
Accessions EAW88426 EAW88427 EAW88428 EAW88429 EAW88430 P10911 AB085901 BAC41200 AB085902 BAC41201 AK296488 BAH12371 AK296529 BAH12378 AK302957 BAH13855 AK313900 BAG36623 AK316416 BAH14787 AL117234 CAB55301 BC160052 AAI60052 DA326503 DA391685 DA723464 DC298193 J03639 AAA52172 X12556 CAA31069 X13230 CAA31617 XM_005262413 XP_005262470 XM_005262414 XP_005262471 XM_006724757 XP_006724820 XM_011531338 XP_011529640 XM_011531339 XP_011529641 NM_001099855 NP_001093325 NM_001171876 NP_001165347 NM_001171877 NP_001165348 NM_001171878 NP_001165349 NM_001171879 NP_001165350 NM_005369 NP_005360
Function Guanine nucleotide exchange factor (GEF) that modulates the Rho family of GTPases. Promotes the conversion of some member of the Rho family GTPase from the GDP-bound to the GTP-bound form. Isoform 1 exhibits no activity toward RHOA, RAC1 or CDC42. Isoform 2 exhibits decreased GEF activity toward CDC42. Isoform 3 exhibits a weak but significant activity toward RAC1 and CDC42. Isoform 4 exhibits significant activity toward RHOA and CDC42. The truncated DBL oncogene is active toward RHOA, RAC1 and CDC42.
Subcellular Location Isoform 3: Membrane. Note=Colocalizes with CDC42 to plasma membrane.
Tissue Specificity Isoform 1 is expressed only in brain. Isoform 3 is expressed in heart, kidney, spleen, liver and testis. Isoform 4 is expressed in brain, heart, kidney, testis, placenta, stomach and peripheral blood. The protein is detectable in brain, heart, kidney, intestine, muscle, lung and testis. {ECO:0000269|PubMed:12445822}.

MCF2/Dbl Antibody - 2089 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell types using MCF2/Dbl Antibody.

Dbl (3) - sc-89 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Dbl (3): sc-89. Immunofluorescence staining of methanol-fixed A-431 cells showing cytoplasmic staining.

Dbl (H-135) - sc-28582 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-MCF2 antibody - ab112588 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-MCF2 antibody (ab112588) at 1/100 dilution + K562 cell line lysate at 35 µg

Anti-MCF2 antibody - ab168730 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-MCF2 antibody (ab168730) at 1 µg/mlLane 1 : MCF2 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugated secondary antibody at 1/2500 dilution

Anti-MCF2 / DBL Antibody (aa804-833, AP) - LS-C262827 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MCF2 / DBL Antibody (aa804-833, APC) - LS-C262828 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MCF2 / DBL Antibody (aa804-833, Azide-free, HRP) - LS-C262831 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MCF2 / DBL Antibody (aa804-833, FITC) - LS-C262830 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MCF2 / DBL Antibody (aa804-833, Biotin) - LS-C262829 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MCF2 / DBL Antibody (aa803-833) - LS-C322904 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MCF2 / DBL Antibody (aa804-833, PE) - LS-C262832 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MCF2 / DBL Antibody (aa804-833) - LS-C164083 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
MCF2 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

MCF2 Antibody - H00004168-B01P-50ug from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-MCF2 antibody produced in mouse - SAB1412726 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
<B>Immunoblotting</B><BR/>Anti-MCF2:<B>Cat. No. SAB1412726</B>: Antibody concentration: 0.1–5 μg/mL. Immunofluorescence band of ~108.4 kDa using MCF2 transfected 293T lysate.<BR/><B>Lane</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

ANTI-MCF2 (C-TERM) antibody produced in rabbit - SAB1301580 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>MCF2 (C-term): <B>Cat. No. SAB1301580</B>: MCF2 in Human brain tissue with MCF2 antibody (C-term) at 10 μg/mL.

MCF2-Antibody-C-term - AP12563b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
MCF2 Antibody (C-term) (Cat. #AP12563b) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the MCF2 antibody detected the MCF2 protein (arrow).

MCF2 Antibody - C-terminal region (OAAB08839) - OAAB08839 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
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