| Gene Symbol |
MCF2
|
| Entrez Gene |
4168
|
| Alt Symbol |
ARHGEF21, DBL
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
MCF.2 cell line derived transforming sequence
|
| Other Description |
Oncogene MCF2 (oncogene DBL)|proto-oncogene DBL|proto-oncogene MCF-2
|
| Swissprots |
B7Z869 E9PH77 Q9UJB3 Q5JYJ4 F5H091 P14919 Q5JYJ2 B7ZAV1 P10911 B7Z3Y5 Q8IUF4 Q8IUF3 Q5JYJ3
|
| Accessions |
EAW88426 EAW88427 EAW88428 EAW88429 EAW88430 P10911 AB085901 BAC41200 AB085902 BAC41201 AK296488 BAH12371 AK296529 BAH12378 AK302957 BAH13855 AK313900 BAG36623 AK316416 BAH14787 AL117234 CAB55301 BC160052 AAI60052 DA326503 DA391685 DA723464 DC298193 J03639 AAA52172 X12556 CAA31069 X13230 CAA31617 XM_005262413 XP_005262470 XM_005262414 XP_005262471 XM_006724757 XP_006724820 XM_011531338 XP_011529640 XM_011531339 XP_011529641 NM_001099855 NP_001093325 NM_001171876 NP_001165347 NM_001171877 NP_001165348 NM_001171878 NP_001165349 NM_001171879 NP_001165350 NM_005369 NP_005360
|
| Function |
Guanine nucleotide exchange factor (GEF) that modulates the Rho family of GTPases. Promotes the conversion of some member of the Rho family GTPase from the GDP-bound to the GTP-bound form. Isoform 1 exhibits no activity toward RHOA, RAC1 or CDC42. Isoform 2 exhibits decreased GEF activity toward CDC42. Isoform 3 exhibits a weak but significant activity toward RAC1 and CDC42. Isoform 4 exhibits significant activity toward RHOA and CDC42. The truncated DBL oncogene is active toward RHOA, RAC1 and CDC42.
|
| Subcellular Location |
Isoform 3: Membrane. Note=Colocalizes with CDC42 to plasma membrane.
|
| Tissue Specificity |
Isoform 1 is expressed only in brain. Isoform 3 is expressed in heart, kidney, spleen, liver and testis. Isoform 4 is expressed in brain, heart, kidney, testis, placenta, stomach and peripheral blood. The protein is detectable in brain, heart, kidney, intestine, muscle, lung and testis. {ECO:0000269|PubMed:12445822}.
|